1H-Pyrazole-3-carboxylic acid, 1-(4-bromophenyl)-5-phenyl-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-3-carboxylic acid, 1-(4-bromophenyl)-5-phenyl-, ethyl ester
CAS No.:62160-91-2
Molecular Formula:C18H15BrN2O2
Molecular Weight:371.233
Hs Code.:

Synonyms:1-(4-bromo-phenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester;

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Chemical Property of 1H-Pyrazole-3-carboxylic acid, 1-(4-bromophenyl)-5-phenyl-, ethyl ester

Chemical Property:

PSA：44.12000
LogP:4.47850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxylic acid, 1-(4-bromophenyl)-5-phenyl-, ethyl ester

There total 4 articles about 1H-Pyrazole-3-carboxylic acid, 1-(4-bromophenyl)-5-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3453-00-7
diethyl benzoylmethylphosphonate

: 27143-10-8
ethoxycarbonylformyl chloride p-bromophenylhydrazone

: 62160-91-2
ethyl 1-(4-bromophenyl)-5-phenyl-1H-pyrazole-3-carboxylate

Guidance literature:: With lithium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 10h; regioselective reaction;
DOI:10.1016/j.tetlet.2013.12.045

Reference yield: 50.0%

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 472800-84-3
ethyl (3Z)-4-hydroxy-2-oxo-4-phenylbut-3-enoate

: 62160-91-2
ethyl 1-(4-bromophenyl)-5-phenyl-1H-pyrazole-3-carboxylate

Guidance literature:: In ethanol; for 1h; Heating;
DOI:10.1016/j.farmac.2004.05.008

Reference yield:

: 98-86-2
acetophenone

: 62160-91-2
ethyl 1-(4-bromophenyl)-5-phenyl-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NaOEt / ethanol

2: 50 percent / ethanol / 1 h / Heating

With sodium ethanolate; In ethanol;
DOI:10.1016/j.farmac.2004.05.008