1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-phenyl-, ethyl ester

Base Information

• Chemical Name: 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-phenyl-, ethyl ester
• CAS No.: 62160-92-3
• Molecular Formula: C18H15ClN2O2
• Molecular Weight: 326.782
• DSSTox Substance ID: DTXSID70392106
• Nikkaji Number: J3.291.820D
• Wikidata: Q82190054

Synonyms:62160-92-3;1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-phenyl-, ethyl ester;ethyl 1-(4-chlorophenyl)-5-phenylpyrazole-3-carboxylate;DTXSID70392106;EU-0046311;ethyl 1-(4-chlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylate;1-(4-Chlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-phenyl-, ethyl ester

Chemical Property:

• PSA: 44.12000
• LogP: 4.36940
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 326.0822054
• Heavy Atom Count: 23
• Complexity: 393

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=NN(C(=C1)C2=CC=CC=C2)C3=CC=C(C=C3)Cl

Technology Process of 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-phenyl-, ethyl ester

There total 4 articles about 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl-(Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoate (88330-79-4,244277-46-1) + N-4-chlorophenylhydrazine (1073-69-4) → 1-(4-chlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester (62160-92-3)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1021/jm0407761

Reference yield: 87.0%

diethyl benzoylmethylphosphonate (3453-00-7) + ethyl 2-chloro[(4-chlorophenyl)hydrazono]acetate (27143-09-5,132839-05-5) → 1-(4-chlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester (62160-92-3)

Guidance literature:

With lithium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 10h; regioselective reaction;

DOI:10.1016/j.tetlet.2013.12.045

Reference yield: 40.0%

4-chlorophenylhydrazine hydrochloride (1073-70-7) + ethyl (3Z)-4-hydroxy-2-oxo-4-phenylbut-3-enoate (472800-84-3) → 1-(4-chlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester (62160-92-3)

Guidance literature:

In ethanol; for 1h; Heating;

DOI:10.1016/j.farmac.2004.05.008

upstream raw materials:

4-chlorophenylhydrazine hydrochloride

ethyl (3Z)-4-hydroxy-2-oxo-4-phenylbut-3-enoate

ethyl-(Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoate

N-4-chlorophenylhydrazine

Downstream raw materials:

[1-(4-chloro-phenyl)-5-phenyl-1H-pyrazol-3-yl]-methanol

3-bromomethyl-1-(4-chlorophenyl)-5-phenyl-1H-pyrazole

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