4-chloro-N-(4-hydroxyphenyl)benzamide

Base Information

• Chemical Name: 4-chloro-N-(4-hydroxyphenyl)benzamide
• CAS No.: 19207-92-2
• Molecular Formula: C13H10 Cl N O2
• Molecular Weight: 247.681
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID20357629
• Nikkaji Number: J307.727F
• Wikidata: Q82137617
• Mol file: 19207-92-2.mol

Synonyms:4-chloro-N-(4-hydroxyphenyl)benzamide;19207-92-2;4-Chloro-4'-hydroxybenzanilide;Oprea1_521172;Oprea1_760259;SCHEMBL2409003;DTXSID20357629;NBFVHUUXPNDPDO-UHFFFAOYSA-N;MFCD00020146;AKOS001082153;4-Chloro-N-(4-hydroxy-phenyl)-benzamide;Benzamide, 4-chloro-N-(4-hydroxyphenyl)-;CS-0221527;EN300-09384;Z56346825

Chemical Property of 4-chloro-N-(4-hydroxyphenyl)benzamide

Chemical Property:

• Vapor Pressure: 3.76E-05mmHg at 25°C
• Boiling Point: 342.6°Cat760mmHg
• Flash Point: 161°C
• PSA: 52.82000
• Density: 1.386g/cm³
• LogP: 3.68190
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 247.0400063
• Heavy Atom Count: 17
• Complexity: 256

Purity/Quality:

99%min ^*data from raw suppliers

4-Chloro-N-(4-hydroxyphenyl)benzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)O)Cl

Technology Process of 4-chloro-N-(4-hydroxyphenyl)benzamide

There total 3 articles about 4-chloro-N-(4-hydroxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-amino-phenol (123-30-8) + 4-chloro-benzoyl chloride (122-01-0) → 4-(4-chloro-benzoylamino)-phenol (19207-92-2)

Guidance literature:

With sodium acetate; In acetic acid; N,N-dimethyl-formamide; for 0.5h;

DOI:10.1023/A:1012409614558

Reference yield:

4-amino-phenol (123-30-8) + para-chlorobenzoic acid (74-11-3) → 4-(4-chloro-benzoylamino)-phenol (19207-92-2)

Guidance literature:

para-chlorobenzoic acid; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at -5 ℃; for 1h;

4-amino-phenol; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1080/14756366.2021.2017911

Reference yield:

→ 4-(4-chloro-benzoylamino)-phenol (19207-92-2)

Guidance literature:

p-Aminophenol, p-Chlorbenzoylchlorid;

upstream raw materials:

4-amino-phenol

4-chloro-benzoyl chloride

para-chlorobenzoic acid

Downstream raw materials:

4-chloro-N-[3-(4-chloro-phenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-yl]-benzamide

4-chloro-N-{4-[2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-benzamide

4-amino-N-(4-chlorobenzoyl)-2-chlorophenol

C₁₃H₈ClNO₂

Refernces

• 1、 Anbar, Hanan S.,El-Awady, Raafat,El-Gamal, Mohammed I.,El-Gamal, Randa,Foster, Paul A.,Potter, Barry V. L.,Zaraei, Seyed-Omar. "A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation". . . Retrieved 2020/03/23.
• 2、 -. "Novel 3/4-((Substitutedbenzamidophenoxy)methyl)-N-hydroxybenzamides/propenamides and its use". Paragraph 0101; 0103; 0104. . Retrieved 2020/03/17.