4-Hydroxy-3-benzylcoumarin

Base Information

• Chemical Name: 4-Hydroxy-3-benzylcoumarin
• CAS No.: 15074-18-7
• Molecular Formula: C16H12 O3
• Molecular Weight: 252.269
• Hs Code.: 2932209090
• Mol file: 15074-18-7.mol

Synonyms:Coumarin,3-benzyl-4-hydroxy- (6CI,7CI,8CI); 3-Benzyl-4-hydroxycoumarin;4-Hydroxy-3-(phenylmethyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-benzylcoumarin

Chemical Property of 4-Hydroxy-3-benzylcoumarin

Chemical Property:

• Vapor Pressure: 2.05E-07mmHg at 25°C
• Melting Point: 205 °C
• Boiling Point: 408.7°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 154.3°C
• PSA: 50.44000
• Density: 1.339g/cm³
• LogP: 3.08940

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-3-benzylcoumarin

There total 16 articles about 4-Hydroxy-3-benzylcoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-hydroxy-3-(phenyl(pyrrolidin-1-yl)methyl)-2H-chromen-2-one (1330776-87-8) → 3-benzyl-4-hydroxycoumarin (15074-18-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1039/c5ra22440c

Reference yield: 90.0%

3H-chromene-2,4-dione (4438-85-1) + benzaldehyde (100-52-7) → 3-benzyl-4-hydroxycoumarin (15074-18-7)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1039/c003588b

Reference yield: 88.0%

3,3'-phenylmethylene-bis-4-hydroxycoumarin (1821-19-8) → 3-benzyl-4-hydroxycoumarin (15074-18-7)

Guidance literature:

With sodium cyanoborohydride; In methanol; for 42h; Heating;

DOI:10.1002/hlca.19910740708

upstream raw materials:

3,3'-phenylmethylene-bis-4-hydroxycoumarin

4-hydroxy[1]benzopyran-2-one

benzaldehyde

3-(phenyl-λ³-iodanylidene)chromane-2,4-dione

Downstream raw materials:

4-Azido-3-benzyl-cumarin

3-Benzyl-4-chlor-cumarin

3-benzyl-4-(2-morpholin-4-yl-ethoxy)-chromen-2-one

(4-Hydroxy-2-oxo-2H-chromen-3-yl)-phenyl-acetic acid