1-Ethyl-2-phenylhydrazine

Base Information

• Chemical Name: 1-Ethyl-2-phenylhydrazine
• CAS No.: 622-82-2
• Molecular Formula: C8H12N2
• Molecular Weight: 136.197
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID50341334
• Nikkaji Number: J136.999G
• Wikidata: Q82111427
• Mol file: 622-82-2.mol

Synonyms:1-Ethyl-2-phenylhydrazine;622-82-2;Hydrazine, 1-ethyl-2-phenyl-;1-Ethyl-2-phenylhydrazine #;SCHEMBL1288189;DTXSID50341334

Chemical Property of 1-Ethyl-2-phenylhydrazine

Chemical Property:

• Refractive Index: 1.5676
• Boiling Point: 240.49°C (rough estimate)
• PKA: 6.31±0.38(Predicted)
• PSA: 24.06000
• Density: 1.0150
• LogP: 2.08690
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 77.3

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNNC1=CC=CC=C1

Technology Process of 1-Ethyl-2-phenylhydrazine

There total 17 articles about 1-Ethyl-2-phenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C26H26N2P(1+)*I(1-) (129502-47-2) → 1-ethyl-2-phenylhydrazine (622-82-2)

Guidance literature:

With sodium hydroxide; at 60 ℃; for 2h;

DOI:10.1055/s-1990-26885

Reference yield: 34.0%

acetaldehyde phenylhydrazone (935-07-9,20488-38-4,27935-60-0) → 1-ethyl-2-phenylhydrazine (622-82-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 ℃; for 1h; Reflux;

DOI:10.1021/acs.orglett.0c02514

Reference yield:

phenylhydrazine (100-63-0) → 1-ethyl-2-phenylhydrazine (622-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: und darauffolgende Oxydation mit Quecksilberoxyd in aether.Loesung

2: alcohol; sodium amalgam

With sodium amalgam; ethanol;

upstream raw materials:

acetaldehyde phenylhydrazone

1-acetyl-2-phenylhydrazine

2-ethyl-1-phenyldiazene

C₂₆H₂₆N₂P⁽¹⁺⁾*I^(1-)

Downstream raw materials:

2,5-diethyl-3-oxo-1-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester

propionic acid-(N-ethyl-N'-phenyl-hydrazide)

2-ethyl-5-methyl-1-phenyl-1,2-dihydro-pyrazol-3-one

N,N-diethyl-N'-phenyl-hydrazine