1,3-Bis(3-fluorophenyl)propan-2-one

Base Information

• Chemical Name: 1,3-Bis(3-fluorophenyl)propan-2-one
• CAS No.: 62291-11-6
• Molecular Formula: C15H12F2O
• Molecular Weight: 246.256
• DSSTox Substance ID: DTXSID80605097
• Wikidata: Q82503242

Synonyms:1,3-Bis(3-fluorophenyl)propan-2-one;62291-11-6;SCHEMBL6864466;DTXSID80605097;AKOS010468747

Chemical Property of 1,3-Bis(3-fluorophenyl)propan-2-one

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 246.08562133
• Heavy Atom Count: 18
• Complexity: 254

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)CC(=O)CC2=CC(=CC=C2)F

Technology Process of 1,3-Bis(3-fluorophenyl)propan-2-one

There total 2 articles about 1,3-Bis(3-fluorophenyl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + m-fluorobenzyl chloride (456-42-8) → 1,3-bis(3-fluorophenyl)acetone (62291-11-6)

Guidance literature:

[(p-methylphenyl)sulfonylmethyl]isonitrile; m-fluorobenzyl chloride; With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; at 25 ℃; for 5h; Green chemistry;

With hydrogenchloride; In dichloromethane; water; for 1h; Green chemistry;

Reference yield: 55.0%

(3-fluorophenyl)acetic acid (331-25-9) → 1,3-bis(3-fluorophenyl)acetone (62291-11-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

Reference yield:

1,3-bis(3-fluorophenyl)acetone (62291-11-6) + methylamine (74-89-5) → 3,5-bis(3-fluorophenyl)-1-methyl-4-piperidinone (62290-79-3) + 3,5-bis(3-fluorophenyl)-N,N-dimethylbispidinone

Guidance literature:

With formaldehyd; In ethanol;

upstream raw materials:

(3-fluorophenyl)acetic acid

[(p-methylphenyl)sulfonylmethyl]isonitrile

m-fluorobenzyl chloride

Downstream raw materials:

3,5-bis(3-fluorophenyl)-1-methyl-4-piperidinone

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