Isoxazole, 5-(chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-

Base Information

Chemical Name:Isoxazole, 5-(chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-
CAS No.:62353-39-3
Molecular Formula:C10H9Cl2NO
Molecular Weight:230.09100
Hs Code.:

Synonyms:5-Chlormethyl-3-(p-chlorphenyl)-4,5-dihydroisoxazol;Isoxazole,5-(chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro;5-chloromethyl-3-(4-chloro-phenyl)-4,5-dihydro-isoxazole;

Suppliers and Price of Isoxazole, 5-(chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(Chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-1,2-oxazole
100mg
$ 265.00

TRC
5-(Chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-1,2-oxazole
50mg
$ 175.00

TRC
5-(Chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-1,2-oxazole
10mg
$ 45.00

AK Scientific
5-(Chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-1,2-oxazole
100mg
$ 283.00

Total 3 raw suppliers

Chemical Property of Isoxazole, 5-(chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-

Chemical Property:

PSA：21.59000
LogP:2.50740

Purity/Quality:

97% ^*data from raw suppliers

5-(Chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-1,2-oxazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Isoxazole, 5-(chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro-

There total 5 articles about Isoxazole, 5-(chloromethyl)-3-(4-chlorophenyl)-4,5-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1023294-62-3
1-(4-chlorophenyl)but-3-en-1-one oxime

: 62353-39-3
3-(4-chlorophenyl)-5-(chloromethyl)-4,5-dihydroisoxazole

Guidance literature:: With N-chloro-succinimide; 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate); sodium carbonate; In acetonitrile; at 80 ℃; Inert atmosphere;
DOI:10.1021/acs.joc.9b02031

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 62353-39-3
3-(4-chlorophenyl)-5-(chloromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 0 - 20 °C

2: Jones reagent / diethyl ether / 1 h / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C

4: palladium diacetate; copper dichloride / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With Jones reagent; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; copper dichloride; In diethyl ether; ethanol; water; dimethyl sulfoxide;
DOI:10.1002/ejoc.201403538

Reference yield:

: 14506-33-3
1-(4-chlorophenyl)but-3-en-1-ol

: 62353-39-3
3-(4-chlorophenyl)-5-(chloromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent / diethyl ether / 1 h / 0 - 20 °C

2: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C

3: palladium diacetate; copper dichloride / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With Jones reagent; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; copper dichloride; In diethyl ether; ethanol; water; dimethyl sulfoxide;
DOI:10.1002/ejoc.201403538