(S)-3-Hydroxy-1-methyl-piperidine

Base Information

• Chemical Name: (S)-3-Hydroxy-1-methyl-piperidine
• CAS No.: 62367-59-3
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 2933399090
• Mol file: 62367-59-3.mol

Synonyms:3-Piperidinol,1-methyl-,(S);(S)-1-Methyl-piperidin-3-ol;(S)-3-HYDROXY-1-METHYL-PIPERIDINE;(S)-3-hydroxy-N-methylpiperidine;(S)-1-methyl-3-piperidinol;

Chemical Property of (S)-3-Hydroxy-1-methyl-piperidine

Chemical Property:

• Boiling Point: 177.6±0.0 °C(Predicted)
• PKA: 14.95±0.20(Predicted)
• PSA: 23.47000
• Density: 1.005±0.06 g/cm3(Predicted)
• LogP: 0.01080

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-Hhydroxy-1-methyl-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Hydroxy-1-methyl-piperidine

There total 9 articles about (S)-3-Hydroxy-1-methyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-3-piperidone (5519-50-6) → (S)-3-hydroxy-1-methylpiperidine (62367-59-3)

Guidance literature:

With (S)-1-phenyl-ethylamine; pyridoxal 5'-phosphate; Halomonas elongata amine transaminase D₅E mutant; In aq. phosphate buffer; dimethyl sulfoxide; at 37 ℃; for 2h; pH=8; Reagent/catalyst; enantioselective reaction; Catalytic behavior; Enzymatic reaction;

DOI:10.1039/c8sc05712e

Reference yield:

3-Hydroxy-1-methylpiperidine (3554-74-3) + vinyl acetate (108-05-4,9003-20-7) → (R)-3-hydroxy-1-methylpiperidine (28808-26-6) + (S)-3-hydroxy-1-methylpiperidine (62367-59-3) + (R)-3-acetoxy-N-methylpiperidine + (S)-3-acetoxy-N-methylpiperidine

Guidance literature:

With Candida antarctica lipase B; at 30 ℃; for 9h; Reagent/catalyst; enantioselective reaction; Inert atmosphere; Large scale; Enzymatic reaction;

DOI:10.3987/COM-16-S(S)28

Reference yield:

1-methyl-3-piperidinyl butyrate (99176-14-4,316353-98-7) → (R)-3-hydroxy-1-methylpiperidine (28808-26-6) + (S)-3-hydroxy-1-methylpiperidine (62367-59-3) + (R)-1-methyl-3-piperidinyl butyrate (316353-98-7)

Guidance literature:

With Bacillus licheniformis subtilisin; water; at 20 ℃; for 16h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1016/j.tetasy.2009.09.007

upstream raw materials:

(S)-3-hydroxypiperidine hydrochloride

formaldehyd

1-methyl-3-piperidinyl butyrate

3-Hydroxy-1-methylpiperidine

Downstream raw materials:

C₁₃H₁₅F₃N₂O₃

C₂₁H₂₄BrF₃N₂O₅S

(S)-1-methylpiperidin-3-yl 2-hydroxy-2,2-diphenylacetate

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