6,8-diethyl-2-hydroxymethyltetrahydrooxazolo(3,2-c)pyrimidine-5,7-(4H,6H)-dione

Base Information

• Chemical Name: 6,8-diethyl-2-hydroxymethyltetrahydrooxazolo(3,2-c)pyrimidine-5,7-(4H,6H)-dione
• CAS No.: 58137-53-4
• Molecular Formula: C₁₁H₁₆N₂O₄
• Molecular Weight: 240.259
• Mol file: 58137-53-4.mol

Synonyms:6,8-diethyl-2-hydroxymethyltetrahydrooxazolo(3,2-c)pyrimidine-5,7-(4H,6H)-dione

Chemical Property of 6,8-diethyl-2-hydroxymethyltetrahydrooxazolo(3,2-c)pyrimidine-5,7-(4H,6H)-dione

Chemical Property:

• Vapor Pressure: 5.41E-07mmHg at 25°C
• Boiling Point: 370.3°Cat760mmHg
• Flash Point: 177.8°C
• PSA: 73.46000
• Density: 1.35g/cm³
• LogP: -0.65440

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,8-diethyl-2-hydroxymethyltetrahydrooxazolo(3,2-c)pyrimidine-5,7-(4H,6H)-dione

There total 3 articles about 6,8-diethyl-2-hydroxymethyltetrahydrooxazolo(3,2-c)pyrimidine-5,7-(4H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

6,8-Diethyl-2-bromomethyl-tetrahydrooxazolo<3,2-c>pyrimidine-5,7(4H,6H)-dione (58137-54-5) + silver(I) acetate (563-63-3) → 6,8-diethyl-2-hydroxymethyl-tetrahydrooxazolo-<3,2-c>pyrimidine-5,7(4H,6H)-dione (58137-53-4)

Guidance literature:

In N,N-dimethyl-formamide; for 10h; Heating;

DOI:10.1002/ardp.19823150510

Reference yield:

6,8-Diethyl-2-bromomethyl-tetrahydrooxazolo<3,2-c>pyrimidine-5,7(4H,6H)-dione (58137-54-5) → 6,8-diethyl-2-hydroxymethyl-tetrahydrooxazolo-<3,2-c>pyrimidine-5,7(4H,6H)-dione (58137-53-4)

Guidance literature:

With sodium hydroxide; silver(I) acetate; Yield given. Multistep reaction; 1.) dimethylformamide, reflux, 10 h, 2.) methanol, water, room temperature, 16 h;

DOI:10.1002/jps.2600710814

Reference yield:

1-allyl-3,5-diethyl-pyrimidine-2,4,6-trione → 6,8-diethyl-2-hydroxymethyl-tetrahydrooxazolo-<3,2-c>pyrimidine-5,7(4H,6H)-dione (58137-53-4)

Guidance literature:

Multistep reaction; (i) Br₂, (ii) AgOAc, (iii) (hydrolysis);

DOI:10.1016/S0040-4039(00)91357-1

upstream raw materials:

6,8-Diethyl-2-bromomethyl-tetrahydrooxazolo<3,2-c>pyrimidine-5,7(4H,6H)-dione

silver(I) acetate