4(1H)-Quinazolinone, 2,8-dichloro-

Base Information

• Chemical Name: 4(1H)-Quinazolinone, 2,8-dichloro-
• CAS No.: 62484-39-3
• Molecular Formula: C8H4Cl2N2O
• Molecular Weight: 215.039
• Mol file: 62484-39-3.mol

Synonyms:2,8-dichloro-3H-quinazolin-4-one;

Chemical Property of 4(1H)-Quinazolinone, 2,8-dichloro-

Chemical Property:

• PSA: 46.01000
• LogP: 2.64220

Purity/Quality:

99% ^*data from raw suppliers

2,8-Dichloro-4(3H)-quinazolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,8-Dichloro-4(3H)-quinazolinone is a useful quinazoline derivative which has been used in the preparation of potent CXCR2 antagonists and dipeptidyl peptidase IV inhibitors.

Technology Process of 4(1H)-Quinazolinone, 2,8-dichloro-

There total 4 articles about 4(1H)-Quinazolinone, 2,8-dichloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,8-trichloroquinazoline (62484-29-1) → 2,8-dichloroquinazolin-4(3H)-one (62484-39-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jm070104l

Reference yield:

8-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (62484-22-4) → 2,8-dichloroquinazolin-4(3H)-one (62484-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; N,N-dimethylaniline / 16 h / Heating

2: aq. NaOH / tetrahydrofuran / 4 h / 20 °C

With sodium hydroxide; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/jm070104l

Reference yield:

2-amino-3-chlorobenzoic acid (6388-47-2) → 2,8-dichloroquinazolin-4(3H)-one (62484-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 26 h / 140 - 180 °C

2: trichlorophosphate / 16 h / Reflux

3: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With sodium hydroxide; trichlorophosphate; In tetrahydrofuran;

upstream raw materials:

2,4,8-trichloroquinazoline

8-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

2-amino-3-chlorobenzoic acid

Downstream raw materials:

2-((2,8-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

8-Chloro-2-phenylquinazolin-4(3H)-one