62484-29-1

Basic information

• Product Name: 2,4,8-TRICHLOROQUINAZOLINE
• Synonyms: 2,4,8-TRICHLOROQUINAZOLINE
• CAS NO: 62484-29-1
• Molecular Formula: C₈H₃Cl₃N₂
• Molecular Weight: 233.485
• Mol File: 62484-29-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 227.5°C at 760 mmHg
• Flash Point: 113.2°C
• Appearance: /
• Density: 1.60
• Vapor Pressure: 0.116mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.68±0.30(Predicted)
• CAS DataBase Reference: 2,4,8-TRICHLOROQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,8-TRICHLOROQUINAZOLINE(62484-29-1)
• EPA Substance Registry System: 2,4,8-TRICHLOROQUINAZOLINE(62484-29-1)

Safety Data

• Hazardous Substances Data: 62484-29-1(Hazardous Substances Data)

Usage

General Description

2,4,8-trichloroquinazoline is a chemical compound with the molecular formula C9H4Cl3N3. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. 2,4,8-trichloroquinazoline is used as an intermediate in the synthesis of certain pharmaceuticals and agrochemicals. It is also used in the manufacturing of dyes, polymers, and other industrial products. 2,4,8-trichloroquinazoline is known to have potential biological activity and is being studied for its potential use in medical research. However, it is important to handle this compound with caution as it may pose health and environmental risks.

InChI:InChI=1/C8H3Cl3N2/c9-5-3-1-2-4-6(5)12-8(11)13-7(4)10/h1-3H

Upstream product

• 74396-74-0 7-Chloroindole-2,3-dione 3-Oxime 
• 62484-22-4 8-chloroquinazoline-2,4-diol 
• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 53312-77-9 2-amino-3-chlorobenzonitrile 
• 62484-22-4 8-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 

Downstream Products

• 62484-39-3 2,8-dichloroquinazolin-4(3H)-one 
• 1107694-84-7 2,8-dichloroquinazoline-4-amine 
• 1616708-00-9 N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide 
• 1616708-01-0 7-chloro-N-(2,4-dimethoxybenzyl)-2-(2,2-dimethoxyethyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine 
• 1616707-97-1 2-(7-chloro-5-(2,4-dimethoxybenzylamino)-[1,2,4]triazolo[1,5-c]quinazolin-2-yl)acetaldehyde 
• 1664398-52-0 7-chloro-5-(2,4-dimethoxyphenyl)-2-(2-(5-fluoroisoindolin-2-yl)ethyl)[1,2,4]triazolo[1,5-c]quinazoline 
• 19407-55-7 8-Chloro-2-phenylquinazolin-4(3H)-one 
• 769158-11-4 2-((2,8-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile 

Relevant articles and documents

One-pot cascade ring enlargement of isatin-3-oximes to 2,4-dichloroquinazolines mediated by bis(trichloromethyl)carbonate and triarylphosphine oxide

An efficient and convenient one-pot cascade synthesis of 2,4-dichloroquinazolines directly from isatin-3-oximes with the addition of bis(trichloromethyl)carbonate and triarylphosphine oxide was developed, leading to substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a range of functional groups. Thus, the method represents a convenient and practical strategy for the synthesis of substituted 2,4-dichloroquinazolines.

HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS

The invention relates to heterocyclic compounds and their use as antibiotics and/or as antibiotic potentiators. The compounds may act as colistin potentiators and SOS inhibitors.

HETEROBICYCLO-SUBSTITUTED-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula Gl (structurally represented): where "RG3" "Rd1" to "Rd4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.