2,4,8-trichloroquinazoline

Base Information

• Chemical Name: 2,4,8-trichloroquinazoline
• CAS No.: 62484-29-1
• Molecular Formula: C8H3Cl3N2
• Molecular Weight: 233.48200
• Hs Code.: 2933990090
• Mol file: 62484-29-1.mol

Synonyms:2,4,8-Trichloro-quinazoline;2,4,8-Trichlor-chinazolin;

Chemical Property of 2,4,8-trichloroquinazoline

Chemical Property:

• Vapor Pressure: 0.116mmHg at 25°C
• Boiling Point: 227.5oC at 760 mmHg
• PKA: -1.68±0.30(Predicted)
• Flash Point: 113.2oC
• PSA: 25.78000
• Density: 1.6
• LogP: 3.59000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2,4,8-Trichloroquinazoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,8-trichloroquinazoline

There total 6 articles about 2,4,8-trichloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

bis(trichloromethyl) carbonate (32315-10-9) + 2-amino-3-chlorobenzonitrile (53312-77-9) → 2,4,8-trichloroquinazoline (62484-29-1)

Guidance literature:

bis(trichloromethyl) carbonate; With triethylamine; Triphenylphosphine oxide; In chlorobenzene; at 20 ℃; for 0.5h; Cooling with ice;

2-amino-3-chlorobenzonitrile; In chlorobenzene; at 120 ℃; for 8h;

DOI:10.3987/COM-12-12466

Reference yield: 87.0%

7-Chloroindole-2,3-dione 3-Oxime (74396-74-0) → 2,4,8-trichloroquinazoline (62484-29-1)

Guidance literature:

With bis(trichloromethyl) carbonate; Tris(4-methoxyphenyl)phosphine oxide; In chlorobenzene; at 120 ℃; for 4h;

DOI:10.1080/10426507.2020.1782910

Reference yield: 76.0%

8-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (62484-22-4) → 2,4,8-trichloroquinazoline (62484-29-1)

Guidance literature:

With trichlorophosphate; for 16h; Reflux;

upstream raw materials:

8-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

bis(trichloromethyl) carbonate

2-amino-3-chlorobenzonitrile

2-amino-3-chlorobenzoic acid

Downstream raw materials:

2,8-dichloroquinazolin-4(3H)-one

2,8-dichloroquinazoline-4-amine

N’-(8-chloro-2-(2,4-dimethoxybenzylamino)quinazolin-4-yl)-3,3-dimethoxypropanehydrazide

7-chloro-N-(2,4-dimethoxybenzyl)-2-(2,2-dimethoxyethyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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