4-Amino-2-chloro-5-methylanisole

Base Information

• Chemical Name: 4-Amino-2-chloro-5-methylanisole
• CAS No.: 62492-46-0
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.62400
• Hs Code.: 2922299090
• Mol file: 62492-46-0.mol

Synonyms:Benzenamine,5-chloro-4-methoxy-2-methyl;2-Amino-4-chlor-5-methoxy-toluol;

Chemical Property of 4-Amino-2-chloro-5-methylanisole

Chemical Property:

• PSA: 35.25000
• LogP: 2.82040

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-4-methoxy-2-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Amino-2-chloro-5-methylanisole

There total 7 articles about 4-Amino-2-chloro-5-methylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-4-chloro-5-methoxymethylbenzene (62492-45-9) → 5-chloro-4-methoxy-2-methylaniline (62492-46-0)

Guidance literature:

With hydrogen; nickel; In methanol;

DOI:10.1002/hlca.19770600134

Reference yield:

2-chloro-5-methylphenol (615-74-7) → 5-chloro-4-methoxy-2-methylaniline (62492-46-0)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) NaNO₂, aq. NaOH, (ii) aq. H₂SO₄

2: HNO₃

3: aq. KOH

4: H₂ / Raney-Ni / methanol

With potassium hydroxide; hydrogen; nitric acid; nickel; In methanol;

DOI:10.1002/hlca.19770600134

Reference yield:

2-chloro-5-methyl-4-nitroso-phenol (62509-09-5) → 5-chloro-4-methoxy-2-methylaniline (62492-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: HNO₃

2: aq. KOH

3: H₂ / Raney-Ni / methanol

With potassium hydroxide; hydrogen; nitric acid; nickel; In methanol;

DOI:10.1002/hlca.19770600134

upstream raw materials:

2-nitro-4-chloro-5-methoxymethylbenzene

N,N-dimethyl-formamide dimethyl acetal

1-chloro-2-fluoro-4-methyl-5-nitrobenzene

2-fluoro-4-methylaniline

Downstream raw materials:

tert-butyl [5-chloro-2-(2-hydroxy-3-methylpentyl)-4-methoxyphenyl]carbamate

1-(2-amino-4-chloro-5-methoxyphenyl)-3-methylpentan-2-ol

tert-butyl (5-chloro-4-methoxy-2-methylphenyl)carbamate

Refernces

• 1、 Kolbah,Blazevic,Hannoun,et al.. "Stereoselective in vitro aromatic ring oxygenations of chiral 1,4 benzodiazepin 2 ones". . p. 265 - 283. Retrieved 2007/10/08.