Benzenepropanoic acid, a-chloro-4-(3,3-dimethylbutoxy)-, ethyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, a-chloro-4-(3,3-dimethylbutoxy)-, ethyl ester
• CAS No.: 62517-09-3
• Molecular Formula: C₁₇H₂₅ClO₃
• Molecular Weight: 312.837
• Mol file: 62517-09-3.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, a-chloro-4-(3,3-dimethylbutoxy)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, a-chloro-4-(3,3-dimethylbutoxy)-, ethyl ester

There total 5 articles about Benzenepropanoic acid, a-chloro-4-(3,3-dimethylbutoxy)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethylbutanol (624-95-3) → 2-Chloro-3-[4-(3,3-dimethyl-butoxy)-phenyl]-propionic acid ethyl ester (62517-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / 50percent aqu. NaOH / cetyltrimethylammonium chloride / dimethylsulfoxide / 2 h / 80 °C

2: H₂ / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature

3: 1.) 33percent NaNO₂/H₂O, conc. HCl, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

With copper(I) oxide; hydrogenchloride; sodium hydroxide; water; hydrogen; sodium nitrite; palladium on activated charcoal; cetyltrimethylammonium chloride; In ethanol; dimethyl sulfoxide; benzene;

Reference yield:

4-chlorobenzonitrile (100-00-5) → 2-Chloro-3-[4-(3,3-dimethyl-butoxy)-phenyl]-propionic acid ethyl ester (62517-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / 50percent aqu. NaOH / cetyltrimethylammonium chloride / dimethylsulfoxide / 2 h / 80 °C

2: H₂ / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature

3: 1.) 33percent NaNO₂/H₂O, conc. HCl, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

With copper(I) oxide; hydrogenchloride; sodium hydroxide; water; hydrogen; sodium nitrite; palladium on activated charcoal; cetyltrimethylammonium chloride; In ethanol; dimethyl sulfoxide; benzene;

Reference yield:

1-(3,3-dimethylbutoxy)-4-nitrobenzene (74401-45-9) → 2-Chloro-3-[4-(3,3-dimethyl-butoxy)-phenyl]-propionic acid ethyl ester (62517-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature

2: 1.) 33percent NaNO₂/H₂O, conc. HCl, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

With copper(I) oxide; hydrogenchloride; water; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; benzene;

upstream raw materials:

3,3-dimethylbutyl bromide

ethyl 2-hydroxy-3-(4-hydroxyphenyl)propionate

ethyl acrylate

3,3-dimethylbutanol