3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene 1,1-Dioxide

Base Information

Chemical Name:3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene 1,1-Dioxide
CAS No.:62521-48-6
Molecular Formula:C9H10O3S
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID50514329

Synonyms:62521-48-6;3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene 1,1-Dioxide;MFCD30537125;3-methyl-1,1-dioxo-2H-1-benzothiophen-3-ol;DTXSID50514329;Benzo[b]thiophene-3-ol, 2,3-dihydro-3-methyl-, 1,1-dioxide;AC1787;AKOS032455862;CS-12392;SY056743;A923008;3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene1,1-Dioxide;3-hydroxy-3-methyl-2,3-dihydro-1-benzothiophene-1,1-dione;3-Hydroxy-3-methyl-2,3-dihydro-1H-1-benzothiophene-1,1-dione;3-hydroxy-3-methyl-2,3-dihydro-1lambda-benzothiophene-1,1-dione

Suppliers and Price of 3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene 1,1-Dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene 1,1-Dioxide

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:198.03506535
Heavy Atom Count:13
Complexity:303

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CS(=O)(=O)C2=CC=CC=C21)O

Technology Process of 3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene 1,1-Dioxide

There total 5 articles about 3-Hydroxy-3-methyl-2,3-dihydrobenzothiophene 1,1-Dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

: 445-27-2
2'-Fluoroacetophenone

: 20277-69-4
sodium methansulfinate

: 62521-48-6
3-hydroxy-3-methyl-2,3-dihydro-1H-1-benzothiophene-1,1-dioxide

Guidance literature:: In dimethyl sulfoxide; at 130 - 150 ℃; for 16h;

Reference yield: 68.0%

: 3323-76-0
1-(2-Methanesulfonyl-phenyl)-ethanone

: 62521-48-6
3-hydroxy-3-methyl-2,3-dihydro-1H-1-benzothiophene-1,1-dioxide

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -80 - 20 ℃; for 10h;
DOI:10.1016/S0040-4020(02)00399-X

Reference yield:

: 19614-16-5
2-bromo-1-(methylsulfanyl)benzene

: 62521-48-6
3-hydroxy-3-methyl-2,3-dihydro-1H-1-benzothiophene-1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / diethyl ether; hexane / 0.5 h / -25 °C

1.2: 73 percent / diethyl ether; hexane / -80 - 20 °C

2.1: 76 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 5 - 10 °C

3.1: 68 percent / LDA / tetrahydrofuran / 10 h / -80 - 20 °C

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0040-4020(02)00399-X