7,2'-Dimethoxyflavone

Base Information

• Chemical Name: 7,2'-Dimethoxyflavone
• CAS No.: 62536-78-1
• Molecular Formula: C17H14O4
• Molecular Weight: 282.29100
• DSSTox Substance ID: DTXSID90350945
• Nikkaji Number: J437.549A
• Wikidata: Q27194444
• Metabolomics Workbench ID: 74535
• ChEMBL ID: CHEMBL3039015
• Mol file: 62536-78-1.mol

Synonyms:7,2'-DIMETHOXYFLAVONE;62536-78-1;7-methoxy-2-(2-methoxyphenyl)chromen-4-one;7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one;7-METHOXY-2-(2-METHOXYPHENYL)- 4H-1-BENZOPYRAN-4-ONE;Spectrum_000914;SpecPlus_000521;7,2'-dimethoxy flavone;Spectrum2_000324;Spectrum3_000597;Spectrum4_001885;Spectrum5_000510;Oprea1_643636;BSPBio_002074;KBioGR_002414;KBioSS_001394;DivK1c_006617;SPBio_000327;SCHEMBL4285153;CHEMBL3039015;KBio1_001561;KBio2_001394;KBio2_003962;KBio2_006530;KBio3_001574;4H-1-Benzopyran-4-one, 7-methoxy-2-(2-methoxyphenyl)-;DTXSID90350945;CHEBI:113549;WVWDHKIZBHIGJE-UHFFFAOYSA-N;CCG-38600;AKOS024285403;PD001603;7-methoxy-2-(2-methoxyphenyl)-1-benzopyran-4-one;BRD-K90574291-001-02-4;Q27194444

Chemical Property of 7,2'-Dimethoxyflavone

Chemical Property:

• PSA: 48.67000
• LogP: 3.47720
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 282.08920892
• Heavy Atom Count: 21
• Complexity: 417

Purity/Quality:

7,2''-Dimethoxyflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C(=O)C=C(O2)C3=CC=CC=C3OC

Technology Process of 7,2'-Dimethoxyflavone

There total 12 articles about 7,2'-Dimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-hydroxy-2-(2-methoxyphenyl)-4H-chromen-4-one + methyl iodide (74-88-4) → 7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one (62536-78-1)

Guidance literature:

With potassium carbonate;

DOI:10.1016/j.bmc.2016.03.064

Reference yield: 12.0%

2,4'-Dimethoxy-2-hydroxychalcone (32272-18-7) → 7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one (62536-78-1) + 7-methoxy-2-(2-methoxy-phenyl)-chroman-4-one (32272-17-6) + (Z)-6-methoxy-2-(2-methoxybenzylidene)benzofuran-3(2H)-one (77764-83-1,108197-53-1)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 72h; Heating;

Reference yield:

1-(2,4-dimethoxy-phenyl)-3-(2-methoxy-phenyl)-propane-1,3-dione → 7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one (62536-78-1)

Guidance literature:

With hydrogen iodide; at 130 ℃;

upstream raw materials:

1-(2-hydroxy-4-methoxy-phenyl)-3-(2-methoxy-phenyl)-propane-1,3-dione

2,4'-Dimethoxy-2-hydroxychalcone

1-(2-hydroxy-4-methoxyphenyl)ethanone

2-methoxybenzoic acid methyl ester

Downstream raw materials:

7,2'-dihydroxyflavone