4-Piperidin-4-ylphenol

Base Information

• Chemical Name: 4-Piperidin-4-ylphenol
• CAS No.: 62614-84-0
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10440998
• Wikidata: Q72500923
• Mol file: 62614-84-0.mol

Synonyms:4-Piperidin-4-ylphenol;4-(piperidin-4-yl)phenol;62614-84-0;Phenol, 4-(4-piperidinyl)-;4-piperidin-4-yl-phenol;4-(4-piperidinyl)phenol;4-(4-hydroxyphenyl)piperidine;MFCD08444690;4-Piperidin-4-ylpheno;SCHEMBL654282;4-(4-hydroxy-phenyl)piperidine;DTXSID10440998;ZDEWVCFSCQUKTE-UHFFFAOYSA-N;AKOS005256332;SB41486;AC-27732;BS-13793;AM20040896;CS-0139586;FT-0692576;EN300-26803;A26726

Chemical Property of 4-Piperidin-4-ylphenol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 322.229 °C at 760 mmHg
• PKA: 9.99±0.30(Predicted)
• Flash Point: 140.834 °C
• PSA: 32.26000
• Density: 1.074 g/cm³
• LogP: 2.18800
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

99.0% ^*data from raw suppliers

4-Piperidin-4-ylpheno 96 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C2=CC=C(C=C2)O
• Uses: 4-(4-Piperidinyl)phenol, is a building block used in various chemical synthesis.

Technology Process of 4-Piperidin-4-ylphenol

There total 13 articles about 4-Piperidin-4-ylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl 4-(4-hydroxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylate (1166820-03-6) → 4-(4-hydroxyphenyl)-1,2,3,6-tetrahydropiperidine (62614-84-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 25 ℃; for 2h; under 3750.38 Torr;

Reference yield: 67.0%

4-(4-methoxyphenyl)-piperidinehydrochloride (6748-48-7) → 4-(4-hydroxyphenyl)-1,2,3,6-tetrahydropiperidine (62614-84-0)

Guidance literature:

With hydrogen bromide; for 2h; Heating;

DOI:10.1248/cpb.48.1978

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 4-(4-hydroxyphenyl)-1,2,3,6-tetrahydropiperidine (62614-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: 17.5 h / -78 - 20 °C

2.1: sodium carbonate; (p-hydroxyphenyl)boronic acid / 1,4-dioxane; water / 0.17 h / Inert atmosphere

2.2: 1 h / 80 °C

3.1: 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 25 °C / 3750.38 Torr

With 5%-palladium/activated carbon; (p-hydroxyphenyl)boronic acid; hydrogen; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water;

upstream raw materials:

4-(1-benzyl-piperidin-4-yl)-phenol

4-(4-methoxyphenyl)-piperidinehydrochloride

1-phenylmethyl-4-piperidone

p-benzyloxyphenylbromide

Downstream raw materials:

3-[4-(4-Hydroxy-phenyl)-piperidin-1-ylmethyl]-6-(4-methoxy-benzoyl)-3H-benzooxazol-2-one

1-(4-fluorobenzoyl)-4-(4-hydroxyphenyl)piperidine

4-(4-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

(S)-N-[2-(3,4-Dichlorophenyl)-4-[4-(4-hydroxyphenyl)piperidino]butyl]-N-methylbenzamide hydrochloride