Technology Process of 2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta(a)naphthalene
There total 11 articles about 2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta(a)naphthalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
for 20h;
Ambient temperature;
DOI:10.1021/jm00179a008
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 0.75 h / 200 - 210 °C
2: 94 percent / HF / 90 h / Ambient temperature
3: 1.) sodium ethoxide / 1.) benzene, 1 h. 2.) benzene, 24 h
4: 1.) sodium ethoxide / 1.) benzene, 2 h, 2.) DMF, 100 deg C, 20 h
5: 48percent HBr, glacial acetic acid / 120 h / Heating
6: H2SO4
7: 27.6 percent / NH3 / methanol / 168 h / Ambient temperature
8: 51 percent / NaBH4 / ethanol / 20 h / Ambient temperature
With
sodium tetrahydroborate; sulfuric acid; hydrogen fluoride; ammonia; hydrogen bromide; sodium ethanolate; acetic acid;
In
methanol; ethanol;
DOI:10.1021/jm00179a008
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) sodium ethoxide / 1.) benzene, 1 h. 2.) benzene, 24 h
2: 1.) sodium ethoxide / 1.) benzene, 2 h, 2.) DMF, 100 deg C, 20 h
3: 48percent HBr, glacial acetic acid / 120 h / Heating
4: H2SO4
5: 27.6 percent / NH3 / methanol / 168 h / Ambient temperature
6: 51 percent / NaBH4 / ethanol / 20 h / Ambient temperature
With
sodium tetrahydroborate; sulfuric acid; ammonia; hydrogen bromide; sodium ethanolate; acetic acid;
In
methanol; ethanol;
DOI:10.1021/jm00179a008
