5670-11-1

Basic information

• Product Name: 8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one
• Synonyms: 1H-Benz[e]inden-1-one, 2,3-dihydro-8-methoxy-
• CAS NO: 5670-11-1
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.2439
• Mol File: 5670-11-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 386°C at 760 mmHg
• Flash Point: 186°C
• Density: 1.225g/cm³
• Vapor Pressure: 3.66E-06mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one(5670-11-1)
• EPA Substance Registry System: 8-methoxy-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one(5670-11-1)

Safety Data

• Hazardous Substances Data: 5670-11-1(Hazardous Substances Data)

Upstream product

• 5060-82-2 7-methoxy-2-naphthol 
• 135653-94-0 7-methoxy-2-trifluoromethanesulfonyloxynaphthalene 
• 103143-23-3 2-(bromomethyl)-7-methoxynaphthalene 
• 5665-20-3 20(hydroxymethyl)-7-methoxynaphthalene 
• 5665-24-7 α-Carboxy-β-(7-methoxy-2-naphthyl)-propionsaeure 
• 5665-25-8 2-(β-carboxyethyl)-7-methoxynaphthalene 

Downstream Products

• 72907-97-2 2-(carbethoxymethyl)-8-methoxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene 
• 72907-99-4 2-(carbethoxymethyl)-8-hydroxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene 
• 72908-00-0 2-(carbamylmethyl)-8-hydroxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene 
• 72908-01-1 2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta[a]naphthalene 
• 72907-96-1 2-ethoxalyl-8-methoxy-1-oxo-2,3-dihydro-1H-cyclopentanaphthalene 
• 3451-02-3 benzene-1,2,3,4-tetracarboxylic acid tetramethyl ester 

Relevant articles and documents

Synthesis and biological evaluation of new naphtho- and quinolinocyclopentane derivatives as potent melatoninergic (MT1/MT2) and serotoninergic (5-HT2C) dual ligands

We recently reported a series of naphthofuranic compounds as constrained agomelatine analogues. Herein, in order to explore alternative ethyl amide side chain rigidification, naphthocyclopentane and quinolinocyclopentane derivatives with various acetamide modulations were synthesized and evaluated at both melatonin (MT1, MT2) and serotonin (5-HT2C) receptors. These modifications has led to compounds with promising dual affinity and high MTs receptors agonist activity. Enantiomeric separation was then performed on selected compounds allowing us to identify levogyre enantiomers (?)-17g and (?)-17k as the highest (MT1, MT2)/5-HT2C dual ligands described nowadays.