1H-Pyrazole-5-carboxamide, N-[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]-3-methyl-1-[3-[S-methyl-N-[(4- methylphenyl)sulfonyl]sulfinimidoyl]phenyl]-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, N-[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]-3-methyl-1-[3-[S-methyl-N-[(4- methylphenyl)sulfonyl]sulfinimidoyl]phenyl]-
CAS No.:629610-35-1
Molecular Formula:C31H29N5O5S3
Molecular Weight:647.8
Hs Code.:

1H-Pyrazole-5-carboxamide,
N-[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]-3-methyl-1-[3-[S-methyl-N-[(4-
methylphenyl)sulfonyl]sulfinimidoyl]phenyl]-

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxamide, N-[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]-3-methyl-1-[3-[S-methyl-N-[(4- methylphenyl)sulfonyl]sulfinimidoyl]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carboxamide, N-[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]-3-methyl-1-[3-[S-methyl-N-[(4- methylphenyl)sulfonyl]sulfinimidoyl]phenyl]-

There total 4 articles about 1H-Pyrazole-5-carboxamide, N-[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]-3-methyl-1-[3-[S-methyl-N-[(4- methylphenyl)sulfonyl]sulfinimidoyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127-65-1
chloroamine-T

: 629610-19-1
5-methyl-2-(3-methylsulfanyl-phenyl)-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

: 629610-35-1
N-[2'-(aminosulfonyl)-1,1'-biphenyl-4-yl]-3-methyl-1-(3-{methyl[(4-methylphenyl)sulfonyl]-sulfinimidoyl}phenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: chloroamine-T; 5-methyl-2-(3-methylsulfanyl-phenyl)-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide; In methanol; at 60 ℃; for 1h;

With trifluoroacetic acid; at 80 ℃; for 0.25h;
DOI:10.1021/jm020578e

Reference yield:

: 1783-81-9
3-methylmercaptoaniline

: 629610-35-1
N-[2'-(aminosulfonyl)-1,1'-biphenyl-4-yl]-3-methyl-1-(3-{methyl[(4-methylphenyl)sulfonyl]-sulfinimidoyl}phenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNO₂; HCl / 0 °C

1.2: SnCl₂

2.1: ethanol / 5 h / Heating

3.1: Me₃Al / CH₂Cl₂; hexane / 0.25 h / 20 °C

3.2: CH₂Cl₂; hexane / 18 h / 40 °C

4.1: methanol / 1 h / 60 °C

4.2: 45 mg / TFA / 0.25 h / 80 °C

With hydrogenchloride; trimethylaluminum; sodium nitrite; In methanol; ethanol; hexane; dichloromethane;
DOI:10.1021/jm020578e

Reference yield:

: 51304-72-4
(3-(methylthio)phenyl)hydrazine

: 629610-35-1
N-[2'-(aminosulfonyl)-1,1'-biphenyl-4-yl]-3-methyl-1-(3-{methyl[(4-methylphenyl)sulfonyl]-sulfinimidoyl}phenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 5 h / Heating

2.1: Me₃Al / CH₂Cl₂; hexane / 0.25 h / 20 °C

2.2: CH₂Cl₂; hexane / 18 h / 40 °C

3.1: methanol / 1 h / 60 °C

3.2: 45 mg / TFA / 0.25 h / 80 °C

With trimethylaluminum; In methanol; ethanol; hexane; dichloromethane;
DOI:10.1021/jm020578e