2-Fluoro-4-methylpyridine

Base Information

• Chemical Name: 2-Fluoro-4-methylpyridine
• CAS No.: 461-87-0
• Molecular Formula: C6H6FN
• Molecular Weight: 111.119
• Hs Code.: 29333990
• European Community (EC) Number: 625-585-5
• DSSTox Substance ID: DTXSID90372041
• Nikkaji Number: J594.817G
• Wikidata: Q72474875
• Mol file: 461-87-0.mol

Synonyms:2-Fluoro-4-methylpyridine;461-87-0;2-Fluoro-4-picoline;Pyridine, 2-fluoro-4-methyl-;2-fluoro-4-methyl-pyridine;2-fluoro-4-methyl pyridine;4-methyl-2-fluoropyridine;MFCD00041224;SCHEMBL11982;ZBFAXMKJADVOGH-UHFFFAOYSA-;DTXSID90372041;2-Fluoro-4-methylpyridine, 98%;BCP22114;AC-451;AKOS005063631;AB01854;CS-W011273;PS-9257;BP-21203;A7215;AM20051205;F0579;FT-0612436;EN300-91300;C91259;Q-101496;InChI=1/C6H6FN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3

Chemical Property of 2-Fluoro-4-methylpyridine

Chemical Property:

• Appearance/Colour: Clear colourless to light yellow liquid
• Refractive Index: n20/D 1.472(lit.)
• Boiling Point: 161.4 °C at 760 mmHg
• PKA: 0.24±0.10(Predicted)
• Flash Point: 51.4 °C
• PSA: 12.89000
• Density: 1.077 g/cm³
• LogP: 1.52910
• Storage Temp.: Room temperature.
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 111.048427358
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)F
• Uses: 2-Fluoro-4-methylpyridine may be used in the preparation of:2-Fluoro-4-(iodomethyl)pyridine4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydroimidazol-2-thione2-fluoro-4-pyridinemethanol2-fluoro-4-pyridinemethanol, 4-methylbenzenesulfonate10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone2-fluoro-3-iodo-5-methylpyridine2-fluoro-4-pyridinecarboxylic acid

Technology Process of 2-Fluoro-4-methylpyridine

There total 9 articles about 2-Fluoro-4-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-Bromo-4-picoline (4926-28-7) → 2-fluoro-4-methylpyridine (461-87-0)

Guidance literature:

With potassium fluoride; In dimethyl sulfoxide; for 0.0333333h; Microwave irradiation;

DOI:10.1016/j.tetlet.2009.07.015

Reference yield: 51.0%

2-Amino-4-methylpyridine (695-34-1) → 2-fluoro-4-methylpyridine (461-87-0)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; 0 deg C to rt;

DOI:10.1248/cpb.38.2446

Reference yield: 46.0%

picoline (108-89-4) → 2-fluoro-4-methylpyridine (461-87-0) + 2-acetylamino-4-methylpyridine (5327-32-2)

Guidance literature:

With water; fluorine; acetonitrile; at -40 - 0 ℃; for 2h;

DOI:10.1080/00397919408019063

upstream raw materials:

2-Amino-4-methylpyridine

picoline

acetonitrile

1-fluoro-4-methylpyridinium tetrafluoroborate

Downstream raw materials:

2-fluoropyridine-4-carboxylic acid

4-methyl-1H-pyridin-2-one

2-fluoro-4-(iodomethyl)-pyridine

4-methyl-2-phenylpyridine

Refernces

• 1、 Shestopalov, Anatoliy M.,Fedorov, Alexander E.,Rodinovskaya, Liudmila A.,Shestopalov, Alexander A.,Gakh, Andrei A.. "Microwave-assisted synthesis of substituted fluoroazines using KF·2H2O". experimental part. p. 5257 - 5259. Retrieved 2009/12/06.
• 2、 -. "Bis-acyloxymethyl derivatives". . . Retrieved 2008/06/13.