1H-Imidazole-1-carboxylic acid, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

Base Information

Chemical Name:1H-Imidazole-1-carboxylic acid, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester
CAS No.:629931-07-3
Molecular Formula:C27H25F7N4O3
Molecular Weight:586.509
Hs Code.:

1H-Imidazole-1-carboxylic acid,
(2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl
]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Imidazole-1-carboxylic acid, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

Chemical Property:

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Technology Process of 1H-Imidazole-1-carboxylic acid, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

There total 1 articles about 1H-Imidazole-1-carboxylic acid, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 629922-66-3
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

: 530-62-1
1,1'-carbonyldiimidazole

: 629931-07-3
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(1-imidazolylcarbonyloxy)piperidine

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 16h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 7647-01-0,15364-23-5
hydrogenchloride

: 629931-07-3
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(1-imidazolylcarbonyloxy)piperidine

: 629931-15-3
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-4-(4-methylpiperazino)carbonyloxy-2-(4-fluoro-2-methylphenyl)piperidine hydrochloride

Guidance literature:: (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(1-imidazolylcarbonyloxy)piperidine; With methyl iodide; In acetonitrile; for 1h; Heating / reflux;

1-methyl-piperazine; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

hydrogenchloride; In water; ethyl acetate;