(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

Base Information

• Chemical Name: (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine
• CAS No.: 629922-66-3
• Molecular Formula: C₂₃H₂₃F₇N₂O₂
• Molecular Weight: 492.437

Synonyms:(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

Chemical Property of (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

There total 2 articles about (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4S)-2-(4-fluoro-2-methyl)phenyl-4-hydroxypiperidine (629956-92-9) + N-(3,5-bistrifluoromethylbenzyl)-N-methyl-aminocarbonyl chloride (629956-38-3) → (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine (629922-66-3)

Guidance literature:

With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 21h;

Reference yield:

(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide (414910-14-8) → (2R,4R)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine + (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine (629922-66-3)

Guidance literature:

Reference yield:

2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4) + (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine (629922-66-3) → (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-{2-(tetrahydropyran-2-yloxy)ethoxy}piperidine

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In water; toluene; at 20 - 70 ℃;

upstream raw materials:

(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide

(2R,4S)-2-(4-fluoro-2-methyl)phenyl-4-hydroxypiperidine

N-(3,5-bistrifluoromethylbenzyl)-N-methyl-aminocarbonyl chloride

Downstream raw materials:

(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-morpholinocarbonyloxypiperidine

(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(1-imidazolylcarbonyloxy)piperidine

(2R,4S)-1-[N-(3,5-bistrifluoromethylbenzyl)-N-methyl]aminocarbonyl-4-{(2S)-5-oxopyrrolidin-2-yl}carbonyloxy-2-(4-fluoro-2-methylphenyl)piperidine

(2R,4S)-1-[N-(3,5-bistrifluoromethylbenzyl)-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-thiomorpholinocarbonyloxypiperidine

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