1-Piperazinecarboxylic acid, 4-methyl-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester, monohydrochloride

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-methyl-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester, monohydrochloride
CAS No.:629931-15-3
Molecular Formula:C29H33F7N4O3.ClH
Molecular Weight:655.056
Hs Code.:

1-Piperazinecarboxylic acid, 4-methyl-,
(2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl
]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester, monohydrochloride

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Chemical Property of 1-Piperazinecarboxylic acid, 4-methyl-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester, monohydrochloride

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Technology Process of 1-Piperazinecarboxylic acid, 4-methyl-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester, monohydrochloride

There total 1 articles about 1-Piperazinecarboxylic acid, 4-methyl-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 7647-01-0,15364-23-5
hydrogenchloride

: 629931-07-3
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(1-imidazolylcarbonyloxy)piperidine

: 629931-15-3
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-4-(4-methylpiperazino)carbonyloxy-2-(4-fluoro-2-methylphenyl)piperidine hydrochloride

Guidance literature:: (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(1-imidazolylcarbonyloxy)piperidine; With methyl iodide; In acetonitrile; for 1h; Heating / reflux;

1-methyl-piperazine; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

hydrogenchloride; In water; ethyl acetate;