Ethyl 4-amino-1-benzyl-1H-imidazole-5-carboxylate

Base Information

• Chemical Name: Ethyl 4-amino-1-benzyl-1H-imidazole-5-carboxylate
• CAS No.: 630413-89-7
• Molecular Formula: C14H17N3O3
• Molecular Weight: 275.307
• Hs Code.: 2933290090
• Mol file: 630413-89-7.mol

Synonyms:ethyl 4-amino-1-{[4-(methyloxy)phenyl]methyl}-1H-imidazole-5-carboxylate;1H-imidazole-5-carboxylic acid;1H-imidazole-5-carboxylic Acid-4-amino-1-[(4-methoxyphenyl)methyl] Ethyl Ester;1-(1,2,3,4-tetrahydronaphthalen-1-yl)-5-imidazolecarboxylic acid methyl ester;1-(1,2,3,4-tetrahydro-1-naphthalenyl)-,methyl ester;3-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER;1-[(4-methoxyphenyl)methyl]-4-amino-5-ethoxycarbonylimidazole;methyl (+-)-1-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole-5-carboxylate;

Chemical Property of Ethyl 4-amino-1-benzyl-1H-imidazole-5-carboxylate

Chemical Property:

• Melting Point: 109-111 °C
• Boiling Point: 478.1±35.0 °C(Predicted)
• PKA: 4.76±0.61(Predicted)
• PSA: 70.14000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 2.27150

Purity/Quality:

ETHYL-4-AMINO-1-BENZYL-1H-IMIDAZOLE-5-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-amino-1-benzyl-1H-imidazole-5-carboxylate

There total 3 articles about Ethyl 4-amino-1-benzyl-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

C10H11N3O + ethyl bromoacetate (105-36-2) → 1-[(4-methoxyphenyl)methyl]-4-amino-5-ethoxycarbonylimidazole (630413-89-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 70 ℃; for 0.05h; Temperature; Microwave irradiation;

Reference yield:

trans-glycine N-[(cyanoimino)methyl]-N-[(4-methoxyphenyl)methyl] Ethyl Ester → 1-[(4-methoxyphenyl)methyl]-4-amino-5-ethoxycarbonylimidazole (630413-89-7)

Guidance literature:

With potassium tert-butylate; In ethanol; at 75 - 85 ℃; for 1h;

Reference yield:

CYANAMID (420-04-2) + N-(4-methoxybenzyl)glycine ethyl ester (60857-16-1) + orthoformic acid triethyl ester (122-51-0) → 1-[(4-methoxyphenyl)methyl]-4-amino-5-ethoxycarbonylimidazole (630413-89-7)

Guidance literature:

CYANAMID; orthoformic acid triethyl ester; for 2h; Reflux;

N-(4-methoxybenzyl)glycine ethyl ester; In diethyl ether; at 20 ℃; for 2h;

With sodium ethanolate; In ethanol; at 20 ℃; for 1h;

upstream raw materials:

CYANAMID

N-(4-methoxybenzyl)glycine ethyl ester

orthoformic acid triethyl ester

ethyl bromoacetate

Downstream raw materials:

1-tert-butyl-3,7-dihydro-7-[(4-methoxyphenyl)methyl]-1H-purine-2,6-dione

7-{[4-(methyloxy)phenyl]methyl}-1-{2-[(phenylmethyl)oxy]phenyl}-3,7-dihydro-1H-purine-2,6-dione

C₁₅H₁₉N₃O₃

C₂₁H₂₁ClN₄O₅