2H-Indol-2-one, 1,3-dihydro-3-(hydroxymethylene)-

Base Information

• Chemical Name: 2H-Indol-2-one, 1,3-dihydro-3-(hydroxymethylene)-
• CAS No.: 63273-23-4
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.15700

Synonyms:3-(hydroxymethylene)-1,3-dihydro-2H-indol-2-one;3-(Hydroxymethylene)indolin-2-one;3-HYDROXYMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE;

Chemical Property of 2H-Indol-2-one, 1,3-dihydro-3-(hydroxymethylene)-

Chemical Property:

• PSA: 49.33000
• LogP: 1.67560

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxymethylene-1,3-dihydro-indol-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Indol-2-one, 1,3-dihydro-3-(hydroxymethylene)-

There total 1 articles about 2H-Indol-2-one, 1,3-dihydro-3-(hydroxymethylene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-oxoindole (59-48-3) + formic acid ethyl ester (109-94-4) → 3-hydroxymethyleneindolin-2-one (63273-23-4)

Guidance literature:

With sodium methylate; In methanol; at 60 ℃; for 1.5h;

DOI:10.1021/ol070971k

Reference yield: 37.0%

2-(4-aminophenyl)acetamide (6633-76-7) + 3-hydroxymethyleneindolin-2-one (63273-23-4) → 2-(4-{[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}phenyl)acetamide

Guidance literature:

In ethanol; at 80 ℃; for 1h;

Reference yield:

3-hydroxymethyleneindolin-2-one (63273-23-4) + p-toluenesulfonyl chloride (98-59-9) → C16H13NO4S

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

DOI:10.1021/ol070971k

upstream raw materials:

2-oxoindole

formic acid ethyl ester

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