6633-76-7

Usage

Uses

Used in Pharmaceutical Industry:
Benzeneacetamide, 4-amino(9CI) is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it a versatile compound in the production of a wide range of products.
Used in Chemical Processes:
Benzeneacetamide, 4-amino(9CI) is used in various chemical processes due to its high melting and boiling points. Its solubility in organic solvents and its structure with a benzene ring, acetamide group, and amino group make it a valuable compound in the chemical industry.

InChI:InChI=1/C8H10N2O/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4H,5,9H2,(H2,10,11)

Upstream product

• 6321-12-6 2-(4-nitrophenyl)acetamide 
• 39552-81-3 methyl p-aminophenylacetate 
• 3544-25-0 p-aminophenylacetonitrile 
• 17194-82-0 2-(4-hydroxyphenyl)acetamide 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 391873-29-3 methyl 4-aminophenylacetate hydrogensulfate 
• 1634-04-4 tert-butyl methyl ether 
• 1197-55-3 4-aminophenylacetic acid 
• 103-81-1 Benzeneacetamide 
• 104-03-0 4-nitrobenzeneacetic acid 

Downstream Products

• 77167-11-4 2-[4-(Toluene-4-sulfonylamino)-phenyl]-acetamide 
• 2510-42-1 6β-[2-(4-amino-phenyl)-acetylamino]-penicillanic acid 
• 1119711-29-3 (2S,5R)-N-[4-(2-Amino-2-oxoethyl) phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide 
• 125314-02-5 3-(4-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 
• 77167-10-3 2-(4-Methanesulfonylamino-phenyl)-acetamide 
• 1606975-08-9 2-(4-((2-cyclopentyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino)phenyl)acetamide 
• 1606974-99-5 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)phenyl)acetamide 
• 1606974-47-3 2-(4-((2-(2,5-dichlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)acetamide hydrochloride 
• 1606973-76-5 2-(4-((2-(3-chlorophenyl)pyridin-4-yl)amino)phenyl)acetamide hydrochloride 
• 1606974-63-3 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)amino)phenyl)acetamide 

Relevant academic research and scientific papers

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald-Hartwig and Chan-Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

TARGETED PEPTIDE CONJUGATES

The present invention relates to the preparation and use of therapeutic compounds for the treatment of diseases at specific subcellular target areas such as specific cellular organelles. In particular, the therapeutic compounds of the invention are specific for modifying enzyme activity within targeted organelles or structures of cells and tissues. Subcellular organelles and structures that may be specifically targeted by compounds of the present invention include lysosomes, autophagasomes, the endoplasmic reticulum, the Golgi complex, peroxisomes, the nucleus, membranes and the mitochondria.

HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

Provided herein are novel heteroaromatic derivatives, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a prodrug, a pharmaceutically acceptable salt or a prodrug thereof, and pharmaceutical compositions containing such compounds. Also provided herein are uses of such compounds or pharmaceutical compositions thereof in the manufacture of a medicament for treating respiratory diseases, especially chronic obstructive pulmonary disease (COPD).

Choline chloride based eutectic solvent: An efficient and reusable solvent system for the synthesis of primary amides from aldehydes and from nitriles

Choline chloride: a 2ZnCl2 based deep eutectic solvent was found to be a simple, green, efficient and new solvent system for the preparation of primary amides from aldehydes. The same catalytic system is also applicable for the preparation of amides from nitriles. Good to excellent yields of primary amides were obtained in both these transformations.

AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

The present invention provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.

Menthylcarboxamides and their use as cooling agents

Described is a new cooling agent represented by Structure I and compositions with known coolers having cooling properties and the application of Structure I in foodstuffs and chewing gum:

Menthylcarboxamides and Their Use as Cooling Agents

Described is a new cooling agent represented by Structure I and compositions with known coolers having cooling properties and the application of Structure I in foodstuffs and chewing gum:

MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

Chemical process

A process for the preparation of a salt of 5-phenylpentanoyl-(S)-arginyl-(S)-alanyl-{(S)-2-[(R)-3-amino-2-oxopyrrolidin-1-yl]propionyl}-(S)-alanyl-(S)-arginyl-(S)-alanyl-4-aminophenylacetamide (SEQ ID NO: 1) which comprises deprotection of a compound of t

Electronic Substituent Effects in the Nitrilase-Catalyzed Hydrolysis of Para-Substituted Benzyl Cyanides

The initial rates of the nitrilase (Novo)-catalyzed hydrolysis of a series of para-substituted benzyl cyanides (R = NO2, Cl, OCH3, OH, NH2) were found to be susceptible to the nature of the para-substituent of the substrate and a Hammett-type linear free energy correlation was observed with ρ = 0.96.In a separate study, effective solubilization of substituted benzyl cyanide substrates having electron-donating groups (OH, NH2, OCH3) was achieved upon mixing with β-cyclodextrin to form 1:1 mol ratio inclusion complexes, but para-substituted benzyl cyanides with electron-withdrawing groups (Cl, NO2) were not fully solubilized under the same conditions.In addition, it was shown that the presence of β-cyclodextrin not only had no inhibitory effect on the enzyme activity, but it actually increased the initial rate of hydrolysis of the unsubstituted benzyl cyanide:β-cyclodextrin inclusion complex.However, the initial rates of hydrolysis were observed to be smaller when β-cyclodextrin was added to the para-substituted benzyl cyanides.