6633-76-7

Basic information

• Product Name: Benzeneacetamide, 4-amino- (9CI)
• Synonyms: Benzeneacetamide, 4-amino- (9CI);4-AMino-benzeneacetaMide
• CAS NO: 6633-76-7
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.1778
• Product Categories: AMINEPRIMARY
• Mol File: 6633-76-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 399.2°C at 760 mmHg
• Flash Point: 195.2°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 1.39E-06mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: Benzeneacetamide, 4-amino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, 4-amino- (9CI)(6633-76-7)
• EPA Substance Registry System: Benzeneacetamide, 4-amino- (9CI)(6633-76-7)

Safety Data

• Hazardous Substances Data: 6633-76-7(Hazardous Substances Data)

Usage

General Description

Benzeneacetamide, 4-amino- (9CI) is a chemical compound with the molecular formula C8H9NO. It is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. Benzeneacetamide, 4-amino- (9CI) is a white solid that is insoluble in water but soluble in organic solvents. It is also known for its high melting and boiling points, making it a versatile compound in various chemical processes. Its structure consists of a benzene ring with an attached acetamide group and an amino group, giving it properties that make it useful in the production of a wide range of products.

InChI:InChI=1/C8H10N2O/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4H,5,9H2,(H2,10,11)

Upstream product

• 391873-29-3 methyl 4-aminophenylacetate hydrogensulfate 
• 17194-82-0 2-(4-hydroxyphenyl)acetamide 
• 104-03-0 4-nitrobenzeneacetic acid 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 3544-25-0 p-aminophenylacetonitrile 
• 1634-04-4 tert-butyl methyl ether 
• 1197-55-3 4-aminophenylacetic acid 
• 103-81-1 Benzeneacetamide 
• 39552-81-3 methyl p-aminophenylacetate 
• 6321-12-6 2-(4-nitrophenyl)acetamide 

Downstream Products

• 1119711-29-3 (2S,5R)-N-[4-(2-Amino-2-oxoethyl) phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide 
• 125314-02-5 3-(4-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 
• 1606975-08-9 2-(4-((2-cyclopentyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino)phenyl)acetamide 
• 1606974-99-5 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)phenyl)acetamide 
• 1606974-47-3 2-(4-((2-(2,5-dichlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)acetamide hydrochloride 
• 1606973-76-5 2-(4-((2-(3-chlorophenyl)pyridin-4-yl)amino)phenyl)acetamide hydrochloride 
• 1606974-63-3 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)amino)phenyl)acetamide 
• 1403886-03-2 2-[4-(8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-ylamino)-phenyl]-acetamide 
• 1366233-10-4 C₂₄H₂₆N₂O₄ 

Relevant articles and documents

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald-Hartwig and Chan-Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

Provided herein are novel heteroaromatic derivatives, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a prodrug, a pharmaceutically acceptable salt or a prodrug thereof, and pharmaceutical compositions containing such compounds. Also provided herein are uses of such compounds or pharmaceutical compositions thereof in the manufacture of a medicament for treating respiratory diseases, especially chronic obstructive pulmonary disease (COPD).

Choline chloride based eutectic solvent: An efficient and reusable solvent system for the synthesis of primary amides from aldehydes and from nitriles

Choline chloride: a 2ZnCl2 based deep eutectic solvent was found to be a simple, green, efficient and new solvent system for the preparation of primary amides from aldehydes. The same catalytic system is also applicable for the preparation of amides from nitriles. Good to excellent yields of primary amides were obtained in both these transformations.