4-Pyridinecarboxylic acid, 2-[[(4-fluorophenyl)amino]thioxomethyl]hydrazide

Base Information

• Chemical Name: 4-Pyridinecarboxylic acid, 2-[[(4-fluorophenyl)amino]thioxomethyl]hydrazide
• CAS No.: 636-12-4
• Molecular Formula: C13H11FN4OS
• Molecular Weight: 290.321
• Mol file: 636-12-4.mol

Synonyms:

Chemical Property of 4-Pyridinecarboxylic acid, 2-[[(4-fluorophenyl)amino]thioxomethyl]hydrazide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarboxylic acid, 2-[[(4-fluorophenyl)amino]thioxomethyl]hydrazide

There total 3 articles about 4-Pyridinecarboxylic acid, 2-[[(4-fluorophenyl)amino]thioxomethyl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

isoniazid (54-85-3,7640-37-1) + 4-fluorophenyl isothiocyanate (1544-68-9) → N-(4'-fluorophenyl)-2-isonicotinoylhydrazine-1-carbothioamide (636-12-4)

Guidance literature:

In ethanol; Reflux;

Reference yield:

ammonium p-fluorophenyldithiocarbamate (19182-34-4) → N-(4'-fluorophenyl)-2-isonicotinoylhydrazine-1-carbothioamide (636-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lead(II) nitrate / water

2: ethanol / Reflux

With lead(II) nitrate; In ethanol; water;

DOI:10.14233/ajchem.2017.20481

Reference yield:

4-fluoroaniline (371-40-4) → N-(4'-fluorophenyl)-2-isonicotinoylhydrazine-1-carbothioamide (636-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / methanol / 1.33 h / Cooling with ice

2: lead(II) nitrate / water

3: ethanol / Reflux

With ammonium hydroxide; lead(II) nitrate; In methanol; ethanol; water;

DOI:10.14233/ajchem.2017.20481

upstream raw materials:

isoniazid

4-fluorophenyl isothiocyanate

4-fluoroaniline

ammonium p-fluorophenyldithiocarbamate

Downstream raw materials:

4-(4-fluorophenyl)-5-(4-pyridinyl)-2,4-dihydro-3H-1,2,4-triazol-3-thione

N-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amine

4-(4'-fluorophenyl)-5-(pyridin-4'-yl)-4H-1,2,4-triazole-3-thiol

Refernces

• 1、 Arif, Muhammad Nouman,Nadeem, Humaira,Paracha, Rehan Zafar,Khan, Arif-Ullah,Imran, Muhammad,Ali, Fawad. "Synthesis, anti-inflammatory, antimicrobial potential and molecular docking studies of 4,5-disubstituted-1,2,4-triazole thioacetate derivatives". . p. 734 - 745. Retrieved 2019/08/26.
• 2、 Bhat,Ghabbour,Kumar,Fun. "New and efficient synthesis of N-(4-substituted phenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amines". . p. 8483 - 8487. Retrieved 2015/12/31.