19182-34-4

Usage

Uses

Used in Pharmaceutical Synthesis:
(4-fluorophenyl)carbamodithioic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into drug molecules, potentially enhancing their efficacy and selectivity for specific biological targets.
Used in Agrochemical Production:
(4-fluorophenyl)carbamodithioic acid also finds application in the production of agrochemicals, where it can be used to develop new pesticides or herbicides. Its incorporation into these products may improve their effectiveness in controlling pests and weeds while minimizing environmental impact.
Used as a Reagent in Organic Chemistry:
(4-fluorophenyl)carbamodithioic acid serves as a valuable reagent in organic chemistry, facilitating various chemical reactions and synthesis processes. Its presence can influence reaction outcomes and provide access to a range of novel organic compounds.
Used in Therapeutic Applications:
Due to its potential biological activities, (4-fluorophenyl)carbamodithioic acid is being explored for use in therapeutic applications. While further research is needed to fully understand its capabilities, it holds promise for contributing to the development of new treatments for various conditions.
It is crucial to handle (4-fluorophenyl)carbamodithioic acid with care, as it may present health risks if not properly managed. Safety precautions should be taken to mitigate any potential hazards associated with (4-fluorophenyl)carbamodithioic acid.

Upstream product

• 75-15-0 carbon disulfide 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 199111-93-8 4-(4-fluorophenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazole-3-thiol 
• 199111-94-9 4-(4'-fluorophenyl)-5-(pyridin-4'-yl)-4H-1,2,4-triazole-3-thiol 
• 636-12-4 N-(4'-fluorophenyl)-2-isonicotinoylhydrazine-1-carbothioamide 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 330-94-9 4-(4-fluorophenyl)thiosemicarbazide 
• 1309469-85-9 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(4-fluorophenyl)thiosemicarbazone 
• 1547-15-5 3‐(4‐fluorophenyl)‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one 
• 117664-62-7 (4-Fluoro-phenyl)-dithiocarbamic acid 3-(3-chloro-phenyl)-4-oxo-2-phenyl-thiazolidin-5-yl ester 
• 117664-61-6 (4-Fluoro-phenyl)-dithiocarbamic acid 3-(4-chloro-phenyl)-4-oxo-2-phenyl-thiazolidin-5-yl ester 
• 117682-43-6 (4-Fluoro-phenyl)-dithiocarbamic acid 4-oxo-2,3-diphenyl-thiazolidin-5-yl ester 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of some new 1,2,4-trizoles

A series of 1,2,4-triazole derivatives were synthesized using appropriate synthetic route and structures were confirmed by IR,1H NMR and elemental analysis. All the synthesized compounds (6a-6h and 7a-7h) were evaluated for antimicrobial activity by determining their minimum inhibitory concentrations (MICs) against a panel of Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed significant antimicrobial activity against Gram-positive bacteria viz. S. aureus, B. subtilis, Gram-negative bacteria viz. E. coli, P. aerugenosa and fungi viz. C. albicans, A. niger. Some of the compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. Compounds 7g, 6g, 6a exhibited good MICs against Gram-positive bacteria and 7f showed better MICs against Gram-negative bacteria compared to reference norfloxacin. Compounds 7f and 7d exhibited MICs which is equipotent to the reference drug ketoconazole.

Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives

The Plasmodium falciparum cysteine protease falcipain-2, one of the most promising targets for antimalarial drug design, plays a key role in parasite survival as a major peptide hydrolase within the hemoglobin degradation pathway. In this work, a series of novel dihydroartemisinin derivatives based on (thio)semicarbazone scaffold were designed and synthesized as potential falcipain-2 inhibitors. The in vitro biological assay indicated that most of the target compounds showed excellent inhibition activity against P. falciparum falcipain-2, with IC50 values in the 0.29-10.63 μM range. Molecular docking studies were performed to investigate the binding affinities and interaction modes for the inhibitors. The preliminary SARs were summarized and could serve as a foundation for further investigation in the development of antimalarial drugs.