5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile

Base Information

• Chemical Name: 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile
• CAS No.: 63644-86-0
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.061
• Hs Code.: 2933399090
• Mol file: 63644-86-0.mol

Synonyms:5-Brom-4,6-dimethyl-3-nitro-[2]pyridylamin;5-Brom-4,6-dimethyl-3-pyridincarbonitril;2-amino-3-nitro-4,6-dimethyl-5-bromo-pyridine;5-bromo-4,6-dimethyl-nicotinonitrile;5-bromo-4,6-dimethyl-3-nitro-[2]pyridylamine;5-Bromo-3-cyano-4,6-dimethylpyridine;2-Pyridinamine,5-bromo-4,6-dimethyl-3-nitro;6-amino-3-bromo-5-nitro-2,4-lutidine;2-amino-5-bromo-4,6-dimethyl-3-nitropyridine;5-bromo-4,6-dimethyl-3-nitro-2-pyridinylamine;5-bromo-4,6-dimethyl-3-nitro-pyridin-2-ylamine;

Chemical Property of 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile

Chemical Property:

• Boiling Point: 274.6±35.0 °C(Predicted)
• PKA: 0.80±0.28(Predicted)
• PSA: 36.68000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 2.33258
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-4,6-dimethylnicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile

There total 4 articles about 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

6-chloro-3-bromo-2,4-dimethylpyridine-5-carbonitrile (42951-71-3) → 5-Bromo-3-cyano-4,6-dimethylpyridine (63644-86-0)

Guidance literature:

With phosphorus; hydrogen iodide; at 140 ℃; for 4h;

DOI:10.1021/jo00200a045

Reference yield:

3-Cyano-4,6-dimethyl-2(1H)-pyridon (769-28-8) → 5-Bromo-3-cyano-4,6-dimethylpyridine (63644-86-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / Bromine / acetic acid / 0.5 h

2: 86 percent / POCl₃/PCl₅ / 8 h / Heating

3: 62 percent / 47percent aqueous HI/red phosphorus / 4 h / 140 °C

With phosphorus; phosphorus pentachloride; hydrogen iodide; bromine; trichlorophosphate; In acetic acid;

DOI:10.1021/jo00200a045

Reference yield:

5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (23819-87-6) → 5-Bromo-3-cyano-4,6-dimethylpyridine (63644-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / POCl₃/PCl₅ / 8 h / Heating

2: 62 percent / 47percent aqueous HI/red phosphorus / 4 h / 140 °C

With phosphorus; phosphorus pentachloride; hydrogen iodide; trichlorophosphate;

DOI:10.1021/jo00200a045

upstream raw materials:

6-chloro-3-bromo-2,4-dimethylpyridine-5-carbonitrile

5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

3-Cyano-4,6-dimethyl-2(1H)-pyridon

Downstream raw materials:

Methyl 4,6-Dimethyl-5-phenylnicotinate

5-bromo-4,6-dimethylpyridine-3-carboxylic acid