23819-87-6

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H7BrN2O/c1-4-6(3-10)8(12)11-5(2)7(4)9/h1-2H3,(H,11,12)

Upstream product

• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 
• 123-54-6 acetylacetone 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 

Downstream Products

• 89694-55-3 5-bromo-4,6-dimethylpyridin-2-ol 
• 42951-71-3 6-chloro-3-bromo-2,4-dimethylpyridine-5-carbonitrile 
• 42951-65-5 5-bromo-4,6-dimethyl-1⁽²⁾H-pyrazolo[3,4-b]pyridin-3-ylamine 
• 1425934-43-5 C₂₇H₂₁BrN₂O₂ 
• 1425934-44-6 2-(5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-4,4-diphenyl-4H-3,1-benz-oxazinium perchlorate 
• 1425934-39-9 C₂₇H₂₂BrN₃O 
• 1425934-40-2 2-(5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-4,4-diphenyl-3,4-dihydroquinazolinium perchlorate 
• 93350-07-3 Methyl 4,6-Dimethyl-5-phenylnicotinate 
• 93350-01-7 5-bromo-4,6-dimethylpyridine-3-carboxylic acid 
• 63644-86-0 5-Bromo-3-cyano-4,6-dimethylpyridine 
• 941693-23-8 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbaldehyde 
• 941693-43-2 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile 
• 941693-40-9 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile 

Relevant academic research and scientific papers

ROR NUCLEAR RECEPTOR MODULATORS

The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.

Synthesis and reactions of 3-cyano-4,6-dimethyl-2-pyridone

Rapid synthesis of 3-cyano-4,6-dimethyl-2-pyridone 3, using piprazine as a catalyst was reported. X-ray data of the 4,6-dimethyl-2-oxo-1,2-dihydropyridine- 3-carbonitrile exhibited its oxo form. Synthesis of isoquinolinecarbonitrile and pyridylpyridazine using compound 3 was investigated. Reactivity of the synthesized pyridone toward different organic reagents was also studied.

Synthetic utility of enaminonitrile moiety in heterocyclic synthesis: Synthesis of some new thienopyrimidines

The hitherto unknown 3-amino-5-bromo-4, 6-dimethylthieno [2, 3-b] pyridine-2-carbonitrile (4) was condensed with p-anisaldehyde affording the Schiff base (5). Acylation of the thienopyridine derivative (4) using freshly distilled acetic anhydride gave a m

Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist

The total synthesis of anibamine, the first and only natural product known as a chemokine receptor OCR5 antagonist, is reported herein. Anibamine was synthesized from acetylacetone and cyanoacetamide in 10 steps.

2,4-diamino-5,6-disubstituted- and 5,6,7-trisubstituted 5-deazapteridines as insecticides

An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: STR1 wherein R1, R2, R3, R4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridines per se.

Herbicidal cyclohexane-1,3-dione derivatives

The invention concerns novel compounds of the formula I STR1 wherein: Z is selected from oxygen and the group --YAn wherein Y is selected from C1 to C6 alkyl and benzyl and An is an anion; k is zero or the integer 1; n is an integer selected from 3 and 4; X is selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, amino, substituted amino and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof; R1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation; R2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl; R3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl; and R4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl. The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

A General Synthesis of 5-Arylnicotinates

Arylboronic acids have been found to couple efficiently with 5-bromonicotinates to yield 5-arylnicotinates.The reaction is considerably more sensitive to steric inhibition in the arylboronic acid component than in the pyridyl bromide 4.The dianion salt of the boronic acid is implicated as the reactive intermediate responsible for the facile coupling reaction.Pure arylboronic acids are best prepared by using triisopropyl borate as the transmetalating agent.