1-[4-(2-Hydroxyethyl)phenoxy]-2,3-epoxypropane

Base Information

• Chemical Name: 1-[4-(2-Hydroxyethyl)phenoxy]-2,3-epoxypropane
• CAS No.: 63659-17-6
• Molecular Formula: C15H20O3
• Molecular Weight: 248.322
• Hs Code.: 2910900090
• Mol file: 63659-17-6.mol

Synonyms:

Chemical Property of 1-[4-(2-Hydroxyethyl)phenoxy]-2,3-epoxypropane

Chemical Property:

• Boiling Point: 358℃
• Flash Point: 121℃
• PSA: 30.99000
• Density: 1.135
• LogP: 2.43330
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

[[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]methyl]oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: [[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]methyl]oxirane (Betaxolol EP Impurity C) is Betaxolol (B328000) impurity.

Technology Process of 1-[4-(2-Hydroxyethyl)phenoxy]-2,3-epoxypropane

There total 11 articles about 1-[4-(2-Hydroxyethyl)phenoxy]-2,3-epoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ betaxolol (63659-18-7) + 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene (63659-17-6)

Guidance literature:

Reference yield: 94.0%

4-[2-(cyclopropylmethoxy)-ethyl]-phenol (63659-16-5) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene (63659-17-6)

Guidance literature:

With pyridine; for 24h; Heating;

Reference yield: 75.0%

1-allyloxy-4-(2-cyclopropylmethoxyethyl)benzene (128645-29-4) → 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene (63659-17-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2005.10.028

upstream raw materials:

4-[2-(cyclopropylmethoxy)-ethyl]-phenol

epichlorohydrin

1,2-Epoxy-3-bromopropane

1-allyloxy-4-(2-cyclopropylmethoxyethyl)benzene

Downstream raw materials:

Acetic acid (S)-1-chloromethyl-2-[4-(2-cyclopropylmethoxy-ethyl)-phenoxy]-ethyl ester

Refernces

• 1、 Joshi, Ramesh A.,Garud, Dinesh R.,Muthukrishnan,Joshi, Rohini R.,Gurjar. "A convenient synthesis of the enantiomerically pure β-blocker (S)-betaxolol using hydrolytic kinetic resolution". . p. 3802 - 3806. Retrieved 2007/10/03.
• 2、 Di Bono,Scilimati. "A chemoenzymatic route to both enantiomers of betaxolol". . p. 699 - 702. Retrieved 2007/10/02.