Phenol, 4-[2-(cyclobutylmethoxy)ethyl]-

Base Information

• Chemical Name: Phenol, 4-[2-(cyclobutylmethoxy)ethyl]-
• CAS No.: 63659-32-5
• Molecular Formula: C13H18O2
• Molecular Weight: 206.285
• Mol file: 63659-32-5.mol

Synonyms:

Chemical Property of Phenol, 4-[2-(cyclobutylmethoxy)ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 4-[2-(cyclobutylmethoxy)ethyl]-

There total 4 articles about Phenol, 4-[2-(cyclobutylmethoxy)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-<(cyclobutylmethoxy)ethyl>-1-(phenylmethoxy)benzene (63659-31-4) → 4-[2-(cyclobutylmethoxy)-ethyl]-phenol (63659-32-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 50 - 60 ℃; under 2585.7 Torr;

DOI:10.1021/jm00389a008

Reference yield:

cyclobutylmethyl 4-methylbenzenesulfonate (13295-53-9) → 4-[2-(cyclobutylmethoxy)-ethyl]-phenol (63659-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h

2: 80 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/jm00389a008

Reference yield:

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester (56441-69-1) → 4-[2-(cyclobutylmethoxy)-ethyl]-phenol (63659-32-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / LiAlH₄ / tetrahydrofuran / 3 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h

3: 80 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr

With lithium aluminium tetrahydride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/jm00389a008

upstream raw materials:

4-<(cyclobutylmethoxy)ethyl>-1-(phenylmethoxy)benzene

cyclobutylmethyl 4-methylbenzenesulfonate

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

Downstream raw materials:

1-{4-[2-(cyclobutylmethoxy)ethyl]-phenoxy}-2,3-epoxy-propane

1-{4-[2-(Cyclobutylmethoxy)-ethyl]-phenoxy}-3-isopropylamino-propan-2-ol

1-[4-(2-Cyclobutylmethoxy-ethyl)-phenoxy]-3-(1-methyl-3-phenyl-propylamino)-propan-2-ol

1-[4-(2-Cyclobutylmethoxy-ethyl)-phenoxy]-3-[3-(4-fluoro-phenyl)-1-methyl-propylamino]-propan-2-ol