2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane

Base Information

• Chemical Name: 2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane
• CAS No.: 63659-33-6
• Molecular Formula: C16H22O3
• Molecular Weight: 262.349
• DSSTox Substance ID: DTXSID00568312
• Mol file: 63659-33-6.mol

Synonyms:63659-33-6;SCHEMBL7294956;2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane;DTXSID00568312;RSYSGZSYFPXHTK-UHFFFAOYSA-N;1-[4-(2cyclobutylmethoxyethyl)phenoxy]-2,3-epoxypropane;1-[4-(2-cyclobutylmethoxy-ethyl)phenoxy]-2,3-epoxypropane;1-[4-(2-cyclobutylmethoxyethyl)-phenoxy]-2,3-epoxypropane;1-[4-(2-cyclobutylmethoxyethyl)phenoxy]-2,3-epoxypropane

Chemical Property of 2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 262.15689456
• Heavy Atom Count: 19
• Complexity: 257

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(C1)COCCC2=CC=C(C=C2)OCC3CO3

Technology Process of 2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane

There total 5 articles about 2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-<(cyclobutylmethoxy)ethyl>-1-(phenylmethoxy)benzene (63659-31-4) → 1-{4-[2-(cyclobutylmethoxy)ethyl]-phenoxy}-2,3-epoxy-propane (63659-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr

2: NaOH / H₂O / 12 h / Ambient temperature

With sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; water;

DOI:10.1021/jm00389a008

Reference yield:

2-(4-benzyloxyphenyl)ethanol (61439-59-6) → 1-{4-[2-(cyclobutylmethoxy)ethyl]-phenoxy}-2,3-epoxy-propane (63659-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h

2: 80 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr

3: NaOH / H₂O / 12 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; water;

DOI:10.1021/jm00389a008

Reference yield:

cyclobutylmethyl 4-methylbenzenesulfonate (13295-53-9) → 1-{4-[2-(cyclobutylmethoxy)ethyl]-phenoxy}-2,3-epoxy-propane (63659-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h

2: 80 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr

3: NaOH / H₂O / 12 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; water;

DOI:10.1021/jm00389a008

upstream raw materials:

4-[2-(cyclobutylmethoxy)-ethyl]-phenol

epichlorohydrin

4-<(cyclobutylmethoxy)ethyl>-1-(phenylmethoxy)benzene

2-(4-benzyloxyphenyl)ethanol

Downstream raw materials:

6-[4-[3-[3-(4-(2-cyclobutylmethoxy-ethyl)phenoxy)-2-hydroxy-propylamino]propoxy]-3-methyl-phenyl]-4,5-dihydro-3(2H)-pyridazinone

6-[4-[2-[3-(4-(2-Cyclobutylmethoxyethyl)phenoxy)-2-hydroxypropylamino]ethylaminocarbonylmethyl]phenyl]-4,5-dihydro-3(2H)-pyridazinone-hydrochloride

6-[3-[2-[3-(4-(2-Cyclobutylmethoxyethyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-3(2H)-pyridazinone

6-[4-[2-[3-(4-(2-Cyclobutylmethoxyethyl)phenoxy)-2-hydroxypropylamino]ethyl]phenyl]-3(2H)-pyridazinone