phenyl(tetrahydro-2H-pyran-4-yl)Methanone

Base Information

• Chemical Name: phenyl(tetrahydro-2H-pyran-4-yl)Methanone
• CAS No.: 639468-72-7
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol file: 639468-72-7.mol

Synonyms:phenyl(tetrahydro-2H-pyran-4-yl)methanone;phenyl-tetrahydropyran-4-yl ketone;phenyl-(tetrahydropyran-4-yl)-methanone;Phenyl-(tetrahydro-pyran-4-yl)-methanone;4-benzoyloxane;Phenyl-tetrahydropyran-4-yl-keton;

Chemical Property of phenyl(tetrahydro-2H-pyran-4-yl)Methanone

Chemical Property:

• Melting Point: 57-58 °C
• Boiling Point: 307.6±35.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.090±0.06 g/cm3(Predicted)
• LogP: 2.29590

Purity/Quality:

≥95% ^*data from raw suppliers

4-benzoyloxane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyl(tetrahydro-2H-pyran-4-yl)Methanone

There total 12 articles about phenyl(tetrahydro-2H-pyran-4-yl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-(tetrahydro-2H-pyran-4-yl)-1-aza-5-stannabicyclo[3.3.3]undecane + benzoyl chloride (98-88-4) → phenyl(tetrahydro-2H-pyran-4-yl)methanone (639468-72-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; In acetonitrile; at 60 ℃; for 12h; Sealed tube;

DOI:10.1002/anie.201609930

Reference yield: 86.7%

N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide (156353-01-4) + phenyllithium (591-51-5) → phenyl(tetrahydro-2H-pyran-4-yl)methanone (639468-72-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield: 74.0%

tetrahydropyran-4-carboxylic acid methyl ester (110238-91-0) + phenyllithium (591-51-5) → phenyl(tetrahydro-2H-pyran-4-yl)methanone (639468-72-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1039/c6md00130k

upstream raw materials:

tetrahydro-2H-pyran-4-carbonitrile

tetrahydro-2H-pyran-4-carbonylchloride

diphenyl cadmium

Tetrahydro-4H-pyran-4-one

Downstream raw materials:

4-phenyl-5-aza-spiro[2.4]hept-4-ene

rac-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol

(S)-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol

(R)-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol