N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide

Base Information

• Chemical Name: N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide
• CAS No.: 156353-01-4
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.212
• Hs Code.: 2932999099
• Mol file: 156353-01-4.mol

Synonyms:N-methoxy-N-methyltetrahydropyran-4-carboxylic acid amide;N-Methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide;tetrahydro-pyran-4-carboxylic acid methoxy-methyl-amide;N-methoxy-N-methyl-tetrahydropyran-4-carboxamide;

Chemical Property of N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide

Chemical Property:

• Boiling Point: 234.9±50.0 °C(Predicted)
• PSA: 38.77000
• Density: 1.090±0.06 g/cm3(Predicted)
• LogP: 0.43280
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Methoxy-N-methyltetrahydropyran-4-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide

There total 9 articles about N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide (156353-01-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 12h;

Reference yield: 96.0%

tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide (156353-01-4)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; at 0 - 20 ℃; for 2h;

Reference yield: 94.0%

tetrahydro-2H-pyran-4-carbonylchloride (40191-32-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide (156353-01-4)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; for 2h;

upstream raw materials:

tetrahydropyran-4-carboxylic acid methyl ester

N,O-dimethylhydroxylamine*hydrochloride

tetrahydro-2H-pyran-4-carbonylchloride

tetrahydro-2H-pyran-4-carboxylic acid

Downstream raw materials:

1-(tetrahydro-2H-pyran-4-yl)ethan-1-one

4-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidine

3-(oxan-4-yl)-1-phenyl-1H-pyrazolo[3,4-c]pyridine