ETHYL 2-AMINO-5-METHOXYBENZOATE

Base Information

• Chemical Name: ETHYL 2-AMINO-5-METHOXYBENZOATE
• CAS No.: 64018-98-0
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922509090
• Mol file: 64018-98-0.mol

Synonyms:Ethyl 5-methoxy-2-aminobenzoate;2-amino-5-methoxybenzoic acid ethyl ester;

Chemical Property of ETHYL 2-AMINO-5-METHOXYBENZOATE

Chemical Property:

• Vapor Pressure: 0.00051mmHg at 25°C
• Melting Point: 38-40 °C
• Boiling Point: 313oC at 760 mmHg
• PKA: 2.71±0.10(Predicted)
• Flash Point: 144.7oC
• PSA: 61.55000
• Density: 1.147g/cm3
• LogP: 2.03530

Purity/Quality:

96% ^*data from raw suppliers

Ethyl 2-amino-5-methoxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-AMINO-5-METHOXYBENZOATE

There total 7 articles about ETHYL 2-AMINO-5-METHOXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2-nitro-5-(methoxy)benzoate (10399-67-4) → 2-amino-5-methoxybenzoic acid ethyl ester (64018-98-0)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In ethanol; for 3h; Reflux;

Reference yield: 91.0%

ethanol (64-17-5) + 2-Amino-5-methoxybenzoic acid (6705-03-9) → 2-amino-5-methoxybenzoic acid ethyl ester (64018-98-0)

Guidance literature:

With hydrogenchloride; for 24h; Heating;

DOI:10.1002/1521-4184(200209)335:7<311::AID-ARDP311>3.0.CO;2-F

Reference yield:

ethyl 5-hydroxy-2-nitrobenzoate (452077-39-3) → 2-amino-5-methoxybenzoic acid ethyl ester (64018-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: iron; ammonium chloride / water; ethanol / 11 h / Reflux

With iron; potassium carbonate; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

ethanol

2-Amino-5-methoxybenzoic acid

ethyl 2-nitro-5-(methoxy)benzoate

5-chloro-2-nitrobenzoic acid

Downstream raw materials:

6-Hydroxy-bentazon

ethyl 5-methoxy-2-(1H-pyrrol-1-yl)benzoate

2-(2-(2-(ethoxycarbonyl)-4-methoxyphenylamino)-2-oxoethoxy)acetic acid

2-[(4-ethoxy-1,4-dioxobutyl)amino]-5-methoxy-benzoic acid ethyl ester

Refernces

• 1、 Lu, Chengrong,Gong, Chao,Zhao, Bei,Hu, Lijuan,Yao, Yingming. "RE[N(SiMe3)2]3-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides". . p. 1154 - 1159. Retrieved 2018/02/10.
• 2、 -. "Preparation technology of 6-hydroxy-bentazone". Paragraph 0105; 0106. . Retrieved 2017/08/28.