10399-67-4

Upstream product

• 64-17-5 ethanol 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 75-03-6 ethyl iodide 
• 63932-00-3 5-methoxy-2-nitrobenzoyl chloride 
• 141-78-6 ethyl acetate 
• 452077-39-3 ethyl 5-hydroxy-2-nitrobenzoate 
• 74-88-4 methyl iodide 
• 610-37-7 5-hydroxy-2-nitrobenzoic acid 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 

Downstream Products

• 60374-42-7 6-Hydroxy-bentazon 
• 1370029-89-2 N'-isopropylidene-5-methoxy-2-nitrobenzohydrazide 
• 1370030-25-3 5-(2-amino-5-methoxyphenyl)-3-benzoyl-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-24-2 5-(2-amino-5-methoxyphenyl)-3-cyclohexanecarbonyl-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-23-1 5-(2-amino-5-methoxyphenyl)-3-cyclopentanecarbonyl-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-22-0 5-(2-amino-5-methoxyphenyl)-3-cyclobutanecarbonyl-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-21-9 5-(2-amino-5-methoxyphenyl)-3-cyclopropylcarbonyl-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-20-8 5-(2-amino-5-methoxyphenyl)-2,2-dimethyl-3-n-pentanoyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-19-5 5-(2-amino-5-methoxyphenyl)-3-n-butyryl-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-18-4 5-(2-amino-5-methoxyphenyl)-2,2-dimethyl-3-n-propyloyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370030-17-3 3-acetyl-5-(2-amino-5-methoxyphenyl)-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370029-91-6 2,2-dimethyl-5-(5-methoxy-2-nitrophenyl)-3-n-propyloyl-2,3-dihydro-1,3,4-thiadiazole 
• 1370029-90-5 3-acetyl-2,2-dimethyl-5-(5-methoxy-2-nitrophenyl)-2,3-dihydro-1,3,4-thiadiazole 
• 1370029-98-3 3-benzoyl-2,2-dimethyl-5-(5-methoxy-2-nitrophenyl)-2,3-dihydro-1,3,4-thiadiazole 

Relevant academic research and scientific papers

Thiadiazoline- And pyrazoline-based carboxamides and carbothioamides: Synthesis and inhibition against nitric oxide synthase

Two new families of pyrazoline and thiadiazoline heterocycles have been developed. Their inhibitory activities against two different isoforms of nitric oxide synthase (inducible and neuronal NOS) are reported. The novel derivatives were synthesized combining the arylthiadiazoline or arylpyrazoline skeleton and a carboxamide or carbothioamide moiety, used as starting material ethyl 2-nitrobenzoates or substituted nitrobenzaldehydes, respectively. The structure-activity relationships of final molecules are discussed in terms of the R1 radical effects in the aromatic ring, the Y atom in the heterocyclic system, the X heteroatom in the main chain, and the R2 substituent in the carboxamide or carbothioamide rest. In general, thiadiazolines (5a-e) inhibit preferentially the neuronal isoform; among them, 5a is the best nNOS inhibitor (74.11% at 1 mM, IC50 = 420 M). In contrast, pyrazolines (6a-r) behave better as iNOS than nNOS inhibitors, 6m being the best molecule of this series (76.86% at 1 mM of iNOS inhibition, IC50 = 130 M) and the most potent of all tested compounds.

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

Preparation technology of 6-hydroxy-bentazone

The invention discloses a preparation technology of 6-hydroxy-3-isopropyl-1H-benzo[c][1,2,6]thiadiazine-4(3H)-keto-2,2-dioxide. The preparation technology includes subjecting 5-chloro-2-nitrobenzoic acid serving as a raw material to hydrolysis reaction an

1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence

The synthesis of new compounds with a 1,3,4-thiadiazole structure, and their in vitro biological evaluation as inhibitors of both neuronal and inducible Nitric Oxide Synthase (nNOS and iNOS) is described. These compounds have been designed by an isosteric

Synthesis of symmetric diester-functionalised Troeger's base analogues

The yields of ester-functionalised Troeger's base analogues are dramatically improved by incorporating an electron-donating group on the aromatic ring and/or enhancing solubil- ity of the aniline unit. In addition to 2,8-diester compounds, 1,7-, 3,9- and 4,10-diester-functionalised Troeger's base analogues have been prepared for the first time.

Relative reactivity of methyl iodide to ethyl iodide in nucleophilic substitution reactions in acetonitrile and partial desolvation accompanying activation

Through the examination of empirical correlations involving activation parameters for nucleophilic substitution of methyl iodide and of ethyl iodide, nucleophiles have been classified into three series: (1) nucleophiles with two equivalent reaction sites, (2) nucleophiles with a chlorine atom in the para-position, and (3) nucleophiles with a single reaction site. Three types of partial desolvation processes accompanying activation have been deduced on the basis of these classifications. A major factor determining the relative reactivity of methyl iodide to ethyl iodide in the substitution reaction of an anionic nucleophile having a single reaction site in acetonitrile (kMeI/kEtI) is suggested to be partial desolvation around the nucleophilic center on going from reactant to transition-state.