2-Hydroxymethyl-4-bromo-4'-fluorobenzophenone

Base Information

Chemical Name:2-Hydroxymethyl-4-bromo-4'-fluorobenzophenone
CAS No.:64169-64-8
Molecular Formula:C14H10BrFO2
Molecular Weight:309.135
Hs Code.:
European Community (EC) Number:613-487-5
DSSTox Substance ID:DTXSID30432895
Wikidata:Q82247023

Synonyms:2-hydroxymethyl-4-bromo-4'-fluorobenzophenone;64169-64-8;SCHEMBL4840874;DTXSID30432895;DSXGDABDEZITPU-UHFFFAOYSA-N

Suppliers and Price of 2-Hydroxymethyl-4-bromo-4'-fluorobenzophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Hydroxymethyl-4-bromo-4'-fluorobenzophenone

Chemical Property:

Vapor Pressure:0mmHg at 25°C
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:307.98482
Heavy Atom Count:18
Complexity:290

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)C2=C(C=C(C=C2)Br)CO)F

Technology Process of 2-Hydroxymethyl-4-bromo-4'-fluorobenzophenone

There total 1 articles about 2-Hydroxymethyl-4-bromo-4'-fluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64169-34-2
5-bromophthalide

: 352-13-6
4-flourophenylmagnesium bromide

: 64169-64-8
4-bromo-4'-fluoro-2-(hydroxymethyl)benzophenone

Guidance literature:: 5-bromophthalide; 4-flourophenylmagnesium bromide; In tetrahydrofuran; dichloromethane; at -6 - -2 ℃;

With water; ammonium chloride; In tetrahydrofuran; dichloromethane;

Reference yield: 79.4%

: 64169-64-8
4-bromo-4'-fluoro-2-(hydroxymethyl)benzophenone

: 64169-65-9
4-bromo-(2-hydroxymethyl)-phenyl-(4'-fluorophenyl)methanol

Guidance literature:: With potassium borohydride; In tetrahydrofuran; ethanol; at 20 - 25 ℃; for 2h;

Reference yield:

: 64169-64-8
4-bromo-4'-fluoro-2-(hydroxymethyl)benzophenone

: 59729-33-8
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / Reflux

2.1: phosphoric acid / 3 h

3.1: N,N-dimethyl-formamide / 4 h / Reflux

4.1: sodium hydride / dimethyl sulfoxide; paraffin oil / 0.17 h / 20 °C / Inert atmosphere

4.2: 0.83 h / 40 °C

With lithium aluminium tetrahydride; phosphoric acid; sodium hydride; In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; paraffin oil;