1-(4-Bromo-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-olhydrochloride

Base Information

Chemical Name:1-(4-Bromo-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-olhydrochloride
CAS No.:488148-10-3
Molecular Formula:C₁₉H₂₃BrFNO₂
Molecular Weight:396.3
Hs Code.:
Mol file:488148-10-3.mol

Synonyms:4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzobromide

Suppliers and Price of 1-(4-Bromo-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-olhydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Descyano4-BromoCitadiol
25mg
$ 180.00

Total 3 raw suppliers

Chemical Property of 1-(4-Bromo-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-olhydrochloride

Chemical Property:

Melting Point:>128°C (dec.)
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

4-Descyano4-BromoCitadiol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-Descyano 4-Bromo Citadiol is an analog of Citadiol (C504800); a precursor of Citalopram (C505000) which is an antidepressant.

Technology Process of 1-(4-Bromo-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-olhydrochloride

There total 4 articles about 1-(4-Bromo-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-olhydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 19070-16-7
3-(N,N-dimethylamino)propylmagnesium chloride

: 64169-34-2
5-bromophthalide

: 352-13-6
4-flourophenylmagnesium bromide

: 488148-10-3
4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzobromide

Guidance literature:: 5-bromophthalide; 4-flourophenylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h;

3-(N,N-dimethylamino)propylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm1005034

Reference yield:

: 64169-34-2
5-bromophthalide

: 488148-10-3
4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzobromide

Guidance literature:: 5-bromophthalide; With 4-flourophenylmagnesium bromide; In tetrahydrofuran; at -10 - -5 ℃; for 4 - 6h;

With 3-(N,N-dimethylamino)propylmagnesium chloride; In tetrahydrofuran; at -10 - 20 ℃; for 9 - 11h;

Reference yield:

: 64169-64-8
4-bromo-4'-fluoro-2-(hydroxymethyl)benzophenone

: 19070-16-7
3-(N,N-dimethylamino)propylmagnesium chloride

: 488148-10-3
4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzobromide

Guidance literature:: 4-bromo-4'-fluoro-2-(hydroxymethyl)benzophenone; 3-(N,N-dimethylamino)propylmagnesium chloride; In tetrahydrofuran; for 4h; Heating / reflux;

With water; ammonium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 0.0833333h;