2H-Isoindole-2-acetamide, N-[[3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2 -quinazolinyl]methyl]-1,3-dihydro-1,3-dioxo-

Base Information

Chemical Name:2H-Isoindole-2-acetamide, N-[[3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2 -quinazolinyl]methyl]-1,3-dihydro-1,3-dioxo-
CAS No.:64194-99-6
Molecular Formula:C₂₇H₂₁Cl₂N₅O₅
Molecular Weight:566.4
Hs Code.:

2H-Isoindole-2-acetamide,
N-[[3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2
-quinazolinyl]methyl]-1,3-dihydro-1,3-dioxo-

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Chemical Property of 2H-Isoindole-2-acetamide, N-[[3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2 -quinazolinyl]methyl]-1,3-dihydro-1,3-dioxo-

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Technology Process of 2H-Isoindole-2-acetamide, N-[[3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2 -quinazolinyl]methyl]-1,3-dihydro-1,3-dioxo-

There total 6 articles about 2H-Isoindole-2-acetamide, N-[[3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2 -quinazolinyl]methyl]-1,3-dihydro-1,3-dioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 6780-38-7
N-phthaloylglycine chloride

: 64194-98-5
N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

: 64194-99-6
3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2-<<(phthaloylglycyl)amino>methyl>qyinazoline

Guidance literature:: In N,N,N,N,N,N-hexamethylphosphoric triamide; for 3h; Ambient temperature;
DOI:10.1021/jm00354a015

Reference yield:

: 2958-36-3,53960-29-5
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

: 64194-99-6
3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2-<<(phthaloylglycyl)amino>methyl>qyinazoline

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

2: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

3: 81.7 percent / dimethylformamide / Ambient temperature

4: 89.6 percent / 30percent HBr-AcOH / 1.5 h / Ambient temperature

5: 50 percent / hexamethylphosphoric acid triamide / 3 h / Ambient temperature

With hydrogen bromide; hydrazine hydrate; acetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00354a015

Reference yield:

: 83520-08-5
2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

: 64194-99-6
3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2-<<(phthaloylglycyl)amino>methyl>qyinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

2: 81.7 percent / dimethylformamide / Ambient temperature

3: 89.6 percent / 30percent HBr-AcOH / 1.5 h / Ambient temperature

4: 50 percent / hexamethylphosphoric acid triamide / 3 h / Ambient temperature

With hydrogen bromide; hydrazine hydrate; acetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00354a015