2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

Base Information

• Chemical Name: 2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester
• CAS No.: 83520-08-5
• Molecular Formula: C₂₅H₂₂Cl₂N₂O₄
• Molecular Weight: 485.367

Synonyms:2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

Chemical Property of 2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

Chemical Property:

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Technology Process of 2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

There total 2 articles about 2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylmethyl cyanomethylcarbamate (3589-41-1) → 2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester (83520-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl gas / diethyl ether / 0 °C

2: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

With hydrogenchloride; acetic acid; In diethyl ether;

DOI:10.1021/jm00354a015

Reference yield:

ethyl 2-benzyloxycarbonylaminoacetimidate hydrochloride (51030-44-5) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → 2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester (83520-08-5)

Guidance literature:

With acetic acid; Multistep reaction; 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h;

DOI:10.1021/jm00354a015

Reference yield: 77.0%

2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester (83520-08-5) → 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline (64194-96-3)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; for 2h; Heating;

DOI:10.1021/jm00354a015

upstream raw materials:

ethyl 2-benzyloxycarbonylaminoacetimidate hydrochloride

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

phenylmethyl cyanomethylcarbamate

Downstream raw materials:

3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

[2-(3-Aminomethyl-5-cyclopropyl-[1,2,4]triazol-4-yl)-5-chloro-phenyl]-(2-chloro-phenyl)-methanone

2-Amino-N-{4-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-cyclopropyl-4H-[1,2,4]triazol-3-ylmethyl}-acetamide

2',5-dichloro-2-<3-<<(benzyloxycarbonyl)amino>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

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