N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

Base Information

Chemical Name:N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide
CAS No.:64194-98-5
Molecular Formula:2BrH*C₁₇H₁₅BrCl₂N₄O
Molecular Weight:603.966
Hs Code.:

Synonyms:N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

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Chemical Property of N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

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Technology Process of N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

There total 4 articles about N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

: 64194-97-4
3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

: 64194-98-5
N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

Guidance literature:: With hydrogen bromide; acetic acid; for 1.5h; Ambient temperature;
DOI:10.1021/jm00354a015

Reference yield:

: 2958-36-3,53960-29-5
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

: 64194-98-5
N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

2: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

3: 81.7 percent / dimethylformamide / Ambient temperature

4: 89.6 percent / 30percent HBr-AcOH / 1.5 h / Ambient temperature

With hydrogen bromide; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00354a015

Reference yield:

: 83520-08-5
2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

: 64194-98-5
N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

2: 81.7 percent / dimethylformamide / Ambient temperature

3: 89.6 percent / 30percent HBr-AcOH / 1.5 h / Ambient temperature

With hydrogen bromide; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00354a015