3-(5-Amino-2-chlorobenzyloxy)pyridine

Base Information

Chemical Name:3-(5-Amino-2-chlorobenzyloxy)pyridine
CAS No.:642084-31-9
Molecular Formula:C12H11ClN2O
Molecular Weight:234.685
Hs Code.:
DSSTox Substance ID:DTXSID50435707
Wikidata:Q82250784
Mol file:642084-31-9.mol

Synonyms:642084-31-9;3-(5-Amino-2-chlorobenzyloxy)pyridine;4-Chloro-3-((pyridin-3-yloxy)methyl)aniline;4-chloro-3-(pyridin-3-yloxymethyl)aniline;SCHEMBL6079265;DTXSID50435707;WHWZWWOANBQXMT-UHFFFAOYSA-N;AKOS015962683;4-chloro-3-(pyridin-3-yloxymethyl)-phenylamine;A1-29204

Suppliers and Price of 3-(5-Amino-2-chlorobenzyloxy)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-Chloro-3-((pyridin-3-yloxy)methyl)aniline 97%
5g
$ 1806.00

Crysdot
4-Chloro-3-((pyridin-3-yloxy)methyl)aniline 97%
1g
$ 673.00

American Custom Chemicals Corporation
3-(5-AMINO-2-CHLOROBENZYLOXY)PYRIDINE 95.00%
5MG
$ 498.38

A1 Biochem Labs
4-Chloro-3-((pyridin-3-yloxy)methyl)aniline 95%
2.5 g
$ 1100.00

Total 2 raw suppliers

Chemical Property of 3-(5-Amino-2-chlorobenzyloxy)pyridine

Chemical Property:

PSA：48.14000
LogP:3.47740
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:234.0559907
Heavy Atom Count:16
Complexity:215

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

4-Chloro-3-((pyridin-3-yloxy)methyl)aniline 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CN=C1)OCC2=C(C=CC(=C2)N)Cl

Technology Process of 3-(5-Amino-2-chlorobenzyloxy)pyridine

There total 8 articles about 3-(5-Amino-2-chlorobenzyloxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 642084-74-0
3-[(2-chloro-5-nitrophenyl)methoxy]pyridine

: 642084-31-9
4-chloro-3-[(pyridin-3-yloxy)methyl]aniline

Guidance literature:: With water; iron; ammonium chloride; In isopropyl alcohol; for 0.5h; Reflux;
DOI:10.1002/cmdc.202000786

Reference yield:

: 80866-80-4
2-chloro-5-nitrobenzyl alcohol

: 642084-31-9
4-chloro-3-[(pyridin-3-yloxy)methyl]aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / PPh₃; CBr₄ / CH₂Cl₂ / 24 h / 20 °C

2.1: NaH / dimethylformamide / 0.2 h / 0 °C

2.2: 25 percent / dimethylformamide / 1 h / 0 °C

3.1: Fe; aq. FeSO₄ / dioxane / 6 h / Heating

With carbon tetrabromide; iron; sodium hydride; iron(II) sulfate; triphenylphosphine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049575n

Reference yield:

: 52427-01-7
2-(bromomethyl)-1-chloro-4-nitrobenzene

: 642084-31-9
4-chloro-3-[(pyridin-3-yloxy)methyl]aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.2 h / 0 °C

1.2: 25 percent / dimethylformamide / 1 h / 0 °C

2.1: Fe; aq. FeSO₄ / dioxane / 6 h / Heating

With iron; sodium hydride; iron(II) sulfate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm049575n