3-(2-Chloro-5-nitro-benzyloxy)-pyridine

Base Information

Chemical Name:3-(2-Chloro-5-nitro-benzyloxy)-pyridine
CAS No.:642084-74-0
Molecular Formula:C12H9ClN2O3
Molecular Weight:264.668
Hs Code.:
DSSTox Substance ID:DTXSID40465518
Wikidata:Q82291527

Synonyms:642084-74-0;3-(2-chloro-5-nitro-benzyloxy)-pyridine;3-[(2-chloro-5-nitrophenyl)methoxy]pyridine;Pyridine, 3-[(2-chloro-5-nitrophenyl)methoxy]-;SCHEMBL6079292;DTXSID40465518;KKBVAMRJNJBVMW-UHFFFAOYSA-N

Suppliers and Price of 3-(2-Chloro-5-nitro-benzyloxy)-pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 3-(2-Chloro-5-nitro-benzyloxy)-pyridine

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:264.0301698
Heavy Atom Count:18
Complexity:285

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CN=C1)OCC2=C(C=CC(=C2)[N+](=O)[O-])Cl

Technology Process of 3-(2-Chloro-5-nitro-benzyloxy)-pyridine

There total 5 articles about 3-(2-Chloro-5-nitro-benzyloxy)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 109-00-2
3-HYDROXYPYRIDINE

: 52427-01-7
2-(bromomethyl)-1-chloro-4-nitrobenzene

: 642084-74-0
3-[(2-chloro-5-nitrophenyl)methoxy]pyridine

Guidance literature:: 3-HYDROXYPYRIDINE; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Cooling with ice;

2-(bromomethyl)-1-chloro-4-nitrobenzene; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield: 6.0%

: 109-00-2
3-HYDROXYPYRIDINE

: 206884-19-7
Methanesulfonic acid 2-chloro-5-nitro-benzyl ester

: 642084-74-0
3-[(2-chloro-5-nitrophenyl)methoxy]pyridine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 16h;
DOI:10.1002/cmdc.202000786

Reference yield:

: 80866-80-4
2-chloro-5-nitrobenzyl alcohol

: 642084-74-0
3-[(2-chloro-5-nitrophenyl)methoxy]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / PPh₃; CBr₄ / CH₂Cl₂ / 24 h / 20 °C

2.1: NaH / dimethylformamide / 0.2 h / 0 °C

2.2: 25 percent / dimethylformamide / 1 h / 0 °C

With carbon tetrabromide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049575n