alpha-Phenyl-trans-cinnamamide

Base Information

• Chemical Name: alpha-Phenyl-trans-cinnamamide
• CAS No.: 20432-29-5
• Molecular Formula: C15H13NO
• Molecular Weight: 223.27
• Hs Code.: 2924299090
• Mol file: 20432-29-5.mol

Synonyms:alpha-Phenyl-trans-cinnamamide;20432-29-5;a-Phenyl-trans-cinnamamide;(E)-2,3-diphenylprop-2-enamide;(E)-2,3-Diphenylacrylamide;cis-.alpha.-Phenylcinnamamide;starbld0005185;SCHEMBL23593943;(2E)-2,3-Diphenyl-2-propenamide;MFCD00083051;AKOS025116659

Chemical Property of alpha-Phenyl-trans-cinnamamide

Chemical Property:

• Vapor Pressure: 1.69E-07mmHg at 25°C
• Melting Point: 127-128 °C
• Boiling Point: 427.1°C at 760 mmHg
• PKA: 15.11±0.50(Predicted)
• Flash Point: 212.1°C
• PSA: 43.09000
• Density: 1.155g/cm³
• LogP: 3.41280
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 223.099714038
• Heavy Atom Count: 17
• Complexity: 283

Purity/Quality:

98%Min ^*data from raw suppliers

alpha-Phenyl-trans-cinnamamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=C(C2=CC=CC=C2)C(=O)N
• Isomeric SMILES: C1=CC=C(C=C1)/C=C(\C2=CC=CC=C2)/C(=O)N

Technology Process of alpha-Phenyl-trans-cinnamamide

There total 7 articles about alpha-Phenyl-trans-cinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(E)-2,3-diphenylpropenoic acid (91-48-5) → (E)-α,β-Diphenylacrylsaeureamid (20432-29-5)

Guidance literature:

(E)-2,3-diphenylpropenoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Sealed tube;

With ammonium bicarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Sealed tube;

DOI:10.1002/open.201500001

Reference yield: 64.0%

carbon monoxide (201230-82-2) + diphenyl acetylene (501-65-5) → (E)-α,β-Diphenylacrylsaeureamid (20432-29-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium chloride; bis[2-(diphenylphosphino)phenyl] ether; at 120 ℃; for 0.2h; under 15201 Torr; regioselective reaction; Glovebox; Schlenk technique; Autoclave;

DOI:10.1021/acs.joc.8b01405

Reference yield:

Ethyl 2-phenylethanoate (101-97-3) → (E)-α,β-Diphenylacrylsaeureamid (20432-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / benzene

2: aq. KOH

With potassium hydroxide; aluminium trichloride; In benzene;

DOI:10.1007/BF00902363

upstream raw materials:

(E)-2,3-diphenylpropenoic acid

trans-α-Phenyl-zimtsaeureimid

(Z)-2,3-diphenylprop-2-enoic acid

Ethyl 2-phenylethanoate

Downstream raw materials:

(2RS,3SR)-2,3-epoxy-2,3-diphenyl-propionic acid amide

(E)-α,β-Diphenylacrylsaeurethioamid