N-(5-ETHYL-1,3,4-THIADIAZOL-2-YL)-4-METHYLBENZENESULFONAMIDE

Base Information

• Chemical Name: N-(5-ETHYL-1,3,4-THIADIAZOL-2-YL)-4-METHYLBENZENESULFONAMIDE
• CAS No.: 64256-73-1
• Molecular Formula: C₁₁H₁₃N₃O₂S₂
• Molecular Weight: 283.375
• Mol file: 64256-73-1.mol

Synonyms:

Chemical Property of N-(5-ETHYL-1,3,4-THIADIAZOL-2-YL)-4-METHYLBENZENESULFONAMIDE

Chemical Property:

• Melting Point: 130 °C
• Boiling Point: 452.0±38.0 °C(Predicted)
• PKA: 6.46±0.40(Predicted)
• PSA: 108.57000
• Density: 1.391±0.06 g/cm3(Predicted)
• LogP: 3.36350

Purity/Quality:

N-(5-ETHYL-1,3,4-THIADIAZOL-2-YL)-4-METHYLBENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-ETHYL-1,3,4-THIADIAZOL-2-YL)-4-METHYLBENZENESULFONAMIDE

There total 2 articles about N-(5-ETHYL-1,3,4-THIADIAZOL-2-YL)-4-METHYLBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-ethyl-1,3,4-thiadiazole (14068-53-2) + p-toluenesulfonyl chloride (98-59-9) → N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-toluenesulfonamide (64256-73-1)

Guidance literature:

With pyridine;

Reference yield:

→ N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-toluenesulfonamide (64256-73-1)

Guidance literature:

5-Amino-2-aethyl-1,3,4-thiadiazol, p-Toluolsulfonsaeurechlorid, Pyridin, 100grad, 2 h;

DOI:10.1021/jm01237a004

Reference yield: 65.0%

pyridine (110-86-1) + copper(ll) sulfate pentahydrate + N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-toluenesulfonamide (64256-73-1) + water (7732-18-5) → [Cu(N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-toluenesulfonamide(-H))2(pyridine)2(H2O)](H2O) (1093103-22-0)

Guidance literature:

In pyridine; water; 4 equivalent of CuSO4*5H2O soln. in pyridine:H2O 1:1 mixt. added dropwise under continuous stirring to organic ligand soln. in pyridine:H2O 2:3 mixt.; stirred at room temp. for 1 h; left to stand at room temp. for 1-3 months; elem. anal.;

DOI:10.1002/zaac.200700214

upstream raw materials:

2-amino-5-ethyl-1,3,4-thiadiazole

p-toluenesulfonyl chloride

Downstream raw materials:

[Cu(N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-toluenesulfonamide(-H))2(pyridine)2(H₂O)](H₂O)

[Cu(N-(5-ethyl-1,3,4-thiadiazol-2-yl)-toluenesulfonamide)2(1,10-phenanthroline)(H₂O)]