4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester

Base Information

• Chemical Name: 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester
• CAS No.: 6436-58-4
• Molecular Formula: C₆H₉NO₂S
• Molecular Weight: 159.209
• Mol file: 6436-58-4.mol

Synonyms:2-methyl-4,5-dihydro-thiazole-4-carboxylic acid methyl ester;2-Methyl-2-thiazolin-carbonsaeure-(4)-methylester;2-Methyl-Δ2-thiazolin-4-carbonsaeure-methylester;rac.-2-Methyl-2-thiazolin-4-carbonsaeure-methylester;2-Methyl-2-thiazolin-4-carbonsaeure-methylester;2-Methyl-Δ2-thiazolin-carbonsaeure-(4)-methylester;

Chemical Property of 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester

Chemical Property:

• Melting Point: 22-24 °C
• Boiling Point: 65-69 °C(Press: 3 Torr)
• PSA: 63.96000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 0.12880

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-methyl-4,5-dihydrothiazole-4-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester

There total 12 articles about 4-Thiazolecarboxylic acid, 4,5-dihydro-2-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C8H12N6O4S2 + acetyl chloride (75-36-5) → methyl 2-methyl-4,5-dihydrothiazole-4-carboxylate (6436-58-4,15263-39-5,45789-42-2,2519-89-3)

Guidance literature:

acetyl chloride; With dmap; phenol; In chloroform; for 0.5h; Cooling with ice;

C₈H₁₂N₆O₄S₂; With triphenylphosphine; In chloroform; Reflux;

Reference yield: 73.0%

dimethyl (2R,2'R)-3,3'-disulfanediylbis(2-azidopropanoate) (1393377-75-7) + acetic acid (64-19-7,77671-22-8) → (4R)-2-methyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester (2519-89-3,6436-58-4,15263-39-5,45789-42-2)

Guidance literature:

acetic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

dimethyl (2R,2'R)-3,3'-disulfanediylbis(2-azidopropanoate); With tributylphosphine; In dichloromethane; at 20 ℃; for 1h; Darkness;

With triphenylphosphine; In dichloromethane; for 5h; Reflux;

DOI:10.1021/jo301030k

Reference yield: 71.0%

C6H11NO3S (1084772-05-3) → (4R)-2-methyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester (2519-89-3,6436-58-4,15263-39-5,45789-42-2)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2008.09.014

upstream raw materials:

L-Cysteine methyl ester

O-ethyl acetimidate

ethyl acetimidate hydrochloride

cysteine methyl ester hydrochloride

Downstream raw materials:

methyl 2-methyl-1,3-thiazole-4-carboxylate

l-cysteine hydrochloride