Methyl 2-methylthiazole-4-carboxylate

Base Information

• Chemical Name: Methyl 2-methylthiazole-4-carboxylate
• CAS No.: 6436-60-8
• Molecular Formula: C6H7NO2S
• Molecular Weight: 157.1903
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID60564310
• Nikkaji Number: J1.493.591F
• Wikidata: Q82448988
• Mol file: 6436-60-8.mol

Synonyms:Methyl 2-methylthiazole-4-carboxylate;6436-60-8;methyl 2-methyl-1,3-thiazole-4-carboxylate;MFCD09870034;2-methyl-thiazole-4-carboxylic acid methyl ester;SCHEMBL496467;AMY4877;DTXSID60564310;FZERNAIKPVSQHU-UHFFFAOYSA-N;Methyl2-methylthiazole-4-carboxylate;AKOS006239289;AC-30473;AS-63124;SY276004;CS-0152802;J-522054

Chemical Property of Methyl 2-methylthiazole-4-carboxylate

Chemical Property:

• Vapor Pressure: 0.0898mmHg at 25°C
• Boiling Point: 224.7°C at 760 mmHg
• Flash Point: 89.7°C
• PSA: 67.43000
• Density: 1.244g/cm³
• LogP: 1.23810
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 157.01974964
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-methylthiazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CS1)C(=O)OC

Technology Process of Methyl 2-methylthiazole-4-carboxylate

There total 15 articles about Methyl 2-methylthiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-acetyl-2,3-dihydro-2,2-dimethyl-1,3-thiazole-4-carboxylate (19791-02-7) → methyl 2-methyl-1,3-thiazole-4-carboxylate (6436-60-8)

Guidance literature:

With sodium acetate; acetic acid; for 19h; Heating;

DOI:10.1002/hlca.19910740206

Reference yield: 97.0%

2-methylthiazole-4-carboxylic acid (35272-15-2) + methyl iodide (74-88-4) → methyl 2-methyl-1,3-thiazole-4-carboxylate (6436-60-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 88.0%

methanol (67-56-1) + 2-methylthiazole-4-carboxylic acid (35272-15-2) → methyl 2-methyl-1,3-thiazole-4-carboxylate (6436-60-8)

Guidance literature:

With thionyl chloride; at -15 ℃; Inert atmosphere; Reflux;

DOI:10.1002/chem.201101615

upstream raw materials:

methyl 2-methyl-4,5-dihydrothiazole-4-carboxylate

methyl 3-acetyl-2,3-dihydro-2,2-dimethyl-1,3-thiazole-4-carboxylate

methyl (4R)-2-methylthiazolidine-4-carboxylate

L-cysteine methyl ester hydrochloride

Downstream raw materials:

2-methylthiazole-4-carbaldehyde