3-Chloro-2-phenylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 3-Chloro-2-phenylimidazo[1,2-a]pyridine
• CAS No.: 64413-91-8
• Molecular Formula: C13H9ClN2
• Molecular Weight: 228.681
• DSSTox Substance ID: DTXSID00357420
• Nikkaji Number: J3.454.256B
• Wikidata: Q82137314
• ChEMBL ID: CHEMBL1456363
• Mol file: 64413-91-8.mol

Synonyms:3-chloro-2-phenylimidazo[1,2-a]pyridine;64413-91-8;3-Chloro-2-phenyl-imidazo[1,2-a]pyridine;MLS001205506;CHEMBL1456363;DTXSID00357420;AKOS000521809;SMR000504893;SR-01000320633;SR-01000320633-1

Chemical Property of 3-Chloro-2-phenylimidazo[1,2-a]pyridine

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 228.0454260
• Heavy Atom Count: 16
• Complexity: 240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N3C=CC=CC3=N2)Cl

Technology Process of 3-Chloro-2-phenylimidazo[1,2-a]pyridine

There total 12 articles about 3-Chloro-2-phenylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-((α-methylbenzylidene)amino)pyridine (120810-61-9) → 2-phenyl-3-chloroimidazo<1,2-a>pyridine (64413-91-8)

Guidance literature:

With thionyl chloride; triethylamine; In chloroform; at 90 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.5b01868

Reference yield: 88.0%

2-phenylimidazo[1,2-a]pyridine (4105-21-9) → 2-phenyl-3-chloroimidazo<1,2-a>pyridine (64413-91-8)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; In dimethyl sulfoxide; at 50 ℃; for 1h; Sealed tube;

Reference yield: 64.0%

2-phenyl-2-(2'-pyridylamino)-1,1,1-trichloroethane (131947-22-3) → 2-phenyl-3-chloroimidazo<1,2-a>pyridine (64413-91-8)

Guidance literature:

at 180 - 200 ℃; for 1h;

upstream raw materials:

N-benzylidenepyridin-2-amine

chloroform

2-phenyl-2-(2'-pyridylamino)-1,1,1-trichloroethane

2-phenylimidazo[1,2-a]pyridine

Downstream raw materials:

2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine

2-phenylimidazo[1,2-a]pyridine